Evidence map›Paper›PMID 37325410›Full record

ReviewJACC. Basic to translational science2023

Calcification in Pulmonary Heart Valve Tissue Engineering: A Systematic Review and Meta-Analysis of Large-Animal Studies.

Dewy C van der Valk, Aleksandra Fomina, Marcelle Uiterwijk, Carlijn R Hooijmans, Anat Akiva, Jolanda Kluin, Carlijn V C Bouten, Anthal I P M Smits

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Basic to translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Dewy C van der ValkDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Aleksandra FominaDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Marcelle UiterwijkHeart Center, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Carlijn R HooijmansDepartment for Health Evidence (Unit SYstematic Review Centre for Laboratory animal Experimentation [SYRCLE]), Radboud University Medical Center, Nijmegen, the Netherlands.
Anat AkivaDepartment of Biochemistry, Radboud University Medical Center, Institute for Molecular Life Sciences, Nijmegen, the Netherlands.
Jolanda KluinHeart Center, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Carlijn V C BoutenDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Anthal I P M SmitsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Eindhoven University of Technology · NLAmsterdam University Medical Centers · NLRadboud University Nijmegen · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-engineered heart valves (TEHVs) are emerging alternatives to current valve prostheses and prospectively a lifelong replacement. Calcification, a pathological complication for biological protheses, has been reported in preclinical TEHV studies. Systematic analysis of its occurrence is missing. This review aims to: 1) systematically review reported calcification of pulmonary TEHVs in large-animal studies; and 2) analyze the influence of engineering methodology (choice of scaffold material, cell preseeding) and animal model (animal species and age) on calcification. Baseline analysis included 80 studies, of which 41 studies containing 108 experimental groups were included in meta-analysis. Inclusion was low because only 55% of studies reported on calcification. Meta-analysis showed an overall average calcification event rate of 35% (95% CI: 28%-43%). Calcification was more prominent (

Indexed as

biomaterialscardiac valve prosthesismineralizationpreclinicalregenerationscaffoldtissue-engineered heart valve

Identifiers

PMID37325410
PMCPMC10264707
OpenAlexW4319988730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.