ArticleACS catalysis2022
In-depth Sequence-Function Characterization Reveals Multiple Pathways to Enhance Enzymatic Activity.
Article in ACS catalysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Evolution and Active Learning Identify Terminal and Distal Determinants for Improved TAL in P-Coumaric Acid Production.Biotechnology and bioengineering · 2026Article
- An engineered disulfide staple restricts lid loop dynamics and alters substrate specificity of phenylalanine ammonia-lyase.bioRxiv : the preprint server for biology · 2026Article
- High throughput screening of eukaryotic release factor 1 variants to enhance noncanonical amino acid incorporation.bioRxiv : the preprint server for biology · 2025Article
- Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens.Cell chemical biology · 2025Review
- Computational studies on the catalytic potential of the double active site for enzyme engineering.Scientific reports · 2024Article
- Integration of metabolomics and transcriptomics reveals the regulation mechanism of the phenylpropanoid biosynthesis pathway in insect resistance traits inHorticulture research · 2024Article
- Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates.Cell chemical biology · 2023Article
- Flow cytometric evaluation of yeast-bacterial cell-cell interactions.Biotechnology and bioengineering · 2023Article
- Lignin and Its Pathway-Associated Phytoalexins Modulate Plant Defense against Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy.Molecular pharmaceutics · 2022Article
- Genome-Wide Identification of Genes Related to Biosynthesis of Phenolic Acid Derivatives inFrontiers in plant science · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Deep mutational scanning (DMS) has recently emerged as a powerful method to study protein sequence-function relationships but it has not been well-explored as a guide to enzyme engineering and identifying pathways by which their catalytic cycle may be improved. We report such a demonstration in this work using a Phenylalanine ammonia-lyase (PAL), which deaminates L-phenylalanine to
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