Evidence map›Paper›PMID 37325195›Full record

ArticleNature reviews. Methods primers2022

Organoids.

Zixuan Zhao, Xinyi Chen, Anna M Dowbaj, Aleksandra Sljukic, Kaitlin Bratlie, Luda Lin, Eliza Li Shan Fong, Gowri Manohari Balachander, Zhaowei Chen, Alice Soragni and 4 more

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 541 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
541citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

541 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Materials today. Bio · 2026
    Article
  9. Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

481 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zixuan ZhaoMechanobiology Institute, National University of Singapore, Singapore.
Xinyi ChenState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Anna M DowbajMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Aleksandra SljukicMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Kaitlin BratlieDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa, USA.
Luda LinDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, California, USA.
Eliza Li Shan FongTranslational Tumor Engineering Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore.
Gowri Manohari BalachanderDepartment of Physiology, Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, Singapore.
Zhaowei ChenState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Alice SoragniDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, California, USA.
Meritxell HuchMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Yi Arial ZengState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Qun WangDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa, USA.
Hanry YuMechanobiology Institute, National University of Singapore, Singapore.

Funding

The Evolution of Sarcoma Drug Sensitivity through Time and SpaceR01CA244729 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOUTROS, PAUL CHRISTOPHER, SORAGNI, ALICE · 2020 to 2024
$3.4M
Evaluating the impact of genetic ancestry on the biology and drug response profile of pheochromocytoma and paraganglioma-derived organoid modelsR01CA264248 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAHIA, PATRICIA LEAL, SORAGNI, ALICE · 2021 to 2025
$3.2M
Targeting p53 conformational defects to arrest carcinogenesisR01CA240718 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SORAGNI, ALICE · 2019 to 2023
$2.0M
Rational Design of Oral Drugs Targeting Mucosa DeliveryR21EB032991 · NIBIB · IOWA STATE UNIVERSITY · PI WANG, QUN · 2022 to 2024
$612k
NCI NIH HHS R01 CA240718NCI NIH HHS R01 CA244729NCI NIH HHS R01 CA264248NIBIB NIH HHS R21 EB032991
6 · The paper itself

Abstract

Organoids have attracted increasing attention because they are simple tissue-engineered cell-based

Identifiers

PMID37325195
PMCPMC10270325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.