A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533.

Rahul D Kavthe, Karthik S Iyer, Juan C Caravez, Bruce H Lipshutz

Abstract read

In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A focus on sustainable method development for greener synthesis.Chemical science · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rahul D KavtheDepartment of Chemistry and Biochemistry, University of California Santa Barbara CA 93106 USA lipshutz@chem.ucsb.edu.

Karthik S IyerDepartment of Chemistry and Biochemistry, University of California Santa Barbara CA 93106 USA lipshutz@chem.ucsb.edu.ORCID https://orcid.org/0000-0003-4566-2721

Juan C CaravezDepartment of Chemistry and Biochemistry, University of California Santa Barbara CA 93106 USA lipshutz@chem.ucsb.edu.ORCID https://orcid.org/0000-0002-5679-7536

Bruce H LipshutzDepartment of Chemistry and Biochemistry, University of California Santa Barbara CA 93106 USA lipshutz@chem.ucsb.edu.ORCID https://orcid.org/0000-0001-9116-7049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 6-step synthesis of the antimalarial drug candidate MMV688533 is reported. Key transformations carried out under aqueous micellar conditions include two Sonogashira couplings and amide bond formation. Compared with the first-generation manufacturing process reported by Sanofi, the current route features ppm levels of palladium loading, less material input, less organic solvent, and no traditional amide coupling reagents. The overall yield is improved ten-fold, from 6.4% to 67%.

Identifiers

PMID37325157

DOI10.1039/d3sc01699d

PMCPMC10266478

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.