ArticleChemical science2023
Asymmetric imino-acylation of alkenes enabled by HAT-photo/nickel cocatalysis.
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 33 citations in OpenAlex.
- Enantioselective rapid assembly of bis-heterocycles by sequential palladium-catalyzed aza-Heck cyclization coupling reaction.Science advances · 2026Article
- Enantioselective Aminosilylation of Alkenes by Palladium/Ming-Phos-Catalyzed Tandem Narasaka-Heck/Silylation Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- 1,5-Hydrogen atom transfer of α-iminyl radical cations: a new platform for relay annulation for pyridine derivatives and axially chiral heterobiaryls.Chemical science · 2024Article
- Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes.Nature communications · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By merging nickel-mediated facially selective aza-Heck cyclization and radical acyl C-H activation promoted by tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst, we accomplish an asymmetric imino-acylation of oxime ester-tethered alkenes with readily available aldehydes as the acyl source, enabling the synthesis of highly enantioenriched pyrrolines bearing an acyl-substituted stereogenic center under mild conditions. Preliminary mechanistic studies support a Ni(i)/Ni(ii)/Ni(iii) catalytic sequence involving the intramolecular migratory insertion of a tethered olefinic unit into the Ni(iii)-N bond as the enantiodiscriminating step.
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Registered trials
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