Evidence map›Paper›PMID 37325142›Full record

ArticleChemical science2023

Cobalt-catalyzed enantioselective desymmetrizing reductive cyclization of alkynyl cyclodiketones.

Ren-Xiao Liang, Heng-Wei Tang, Jia-Liang Liu, Jian-Feng Xu, Ling-Jia Chen, Yi-Xia Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Chiral ruthenium complex/PhScience advances · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ren-Xiao LiangCollege of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology Chaowang Road 18# Hangzhou 310014 China liangrx@zjut.edu.cn yxjia@zjut.edu.cn.ORCID https://orcid.org/0000-0003-0931-1975
Heng-Wei TangCollege of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology Chaowang Road 18# Hangzhou 310014 China liangrx@zjut.edu.cn yxjia@zjut.edu.cn.
Jia-Liang LiuCollege of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology Chaowang Road 18# Hangzhou 310014 China liangrx@zjut.edu.cn yxjia@zjut.edu.cn.
Jian-Feng XuCollege of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology Chaowang Road 18# Hangzhou 310014 China liangrx@zjut.edu.cn yxjia@zjut.edu.cn.
Ling-Jia ChenCollege of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology Chaowang Road 18# Hangzhou 310014 China liangrx@zjut.edu.cn yxjia@zjut.edu.cn.
Yi-Xia JiaCollege of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology Chaowang Road 18# Hangzhou 310014 China liangrx@zjut.edu.cn yxjia@zjut.edu.cn.ORCID https://orcid.org/0000-0001-7936-0049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A highly enantioselective cobalt-catalyzed desymmetrizing reductive cyclization of alkynyl cyclodiketones has been developed. Under mild reaction conditions by employing HBpin as a reducing agent and ferrocene-based PHOX as a chiral ligand, a series of polycyclic tertiary allylic alcohols bearing contiguous quaternary stereocenters are achieved in moderate to excellent yields with excellent enantioselectivities (up to 99%). Broad substrate scope and high functional group compatibility are observed in this reaction. A CoH-catalyzed pathway involving alkyne hydrocobaltation followed by nucleophilic addition to the C[double bond, length as m-dash]O bond is proposed. Synthetic transformations of the product are conducted to demonstrate the practical utilities of this reaction.

Identifiers

PMID37325142
PMCPMC10266457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.