ReviewFrontiers in psychiatry2023
Sleep disorders in chronic pain and its neurochemical mechanisms: a narrative review.
Review in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Sleep Disorders Among Patients Diagnosed with Chronic Pancreatitis: A Systematic Review.Digestive diseases and sciences · 2026Pooled it
- Sleep disorders in functional neurological disorder - a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Sleep disturbances and sleep quality among individuals diagnosed with osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Is endometriosis associated with poor sleep quality? A meta-analysis.Women's health (London, England)Pooled it
- Sleep patterns of Canadian women across the life course: A systematic review.Women's health (London, England)Pooled it
- Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial.Nature medicine · 2025Trial
- Effect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial.Nature and science of sleep · 2025Trial
- Neurobiological and Neuroimmune Mechanisms Linking Chronic Pain, Sleep Disturbances and Mental Health Disorders.International journal of molecular sciences · 2026Review
- Sleep Disturbances in Patients with Complex Regional Pain Syndrome: A Pilot Exploratory Study on Pain Characteristics, Functional Impairment, and Psychological Factors.Brain sciences · 2026Article
- Exploring tobacco, cannabis, and pain-related sleep disturbance among people with and without HIV enrolled in a tobacco smoking cessation trial.Drug and alcohol dependence · 2026Article
- Longitudinal associations of chronic pain and sleep quality with frailty progression in community-dwelling older adults.Aging clinical and experimental research · 2026Article
- Rotator cuff injury disrupts sleep architecture in mice and exhibits a light-dark phase-dependent pattern.BMC musculoskeletal disorders · 2026Article
- Nocturnal pain and pain sensitivity-related symptoms are associated with poor sleep quality in patients with hip osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Neuromodulation strategies in postburn care for pain rehabilitation and scar remodelling.Communications medicine · 2026Review
- Propofol treatment correlates with changes in pain sensitivity and thalamocortical glutamate/GABA balance in sleep-deprived mice.Journal of anesthesia and translational medicine · 2026Article
- Melatonin as an Integrative Adjunct in Multimodal Analgesia: Linking Circadian Regulation, Anti-Inflammatory Modulation, and Opioid-Sparing Mechanisms.International journal of molecular sciences · 2026Review
- Quality of life and associated determinants of chronic pain among patients attending a primary healthcare clinic in Gqeberha: A cross-sectional study.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
- Considerations for a Mind-Body Program for Latine Adults with Chronic Pain and Cognitive Impairment: A Qualitative Study with Healthcare Providers.Journal of pain research · 2026Article
- Computational analysis of therapeutic potential for simplifiedFrontiers in pharmacology · 2026Article
- Resting-State Heart Rate Variability and Symptom-Level Conditional Associations in Hospitalized Patients with Musculoskeletal Pain: An Exploratory Cross-Sectional Network Analysis.Journal of pain research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain (CP) is a prevalent problem, and more than half of patients with CP have sleep disorders. CP comorbidity with sleep disorders imposes immense suffering and seriously affects the patient's quality of life, which is a challenging issue encountered by clinicians. Although the reciprocal interactions between pain and sleep have been studied to some degree, there is still a lack of awareness and comprehensive description of CP comorbidity with sleep disorders. In this narrative review article, we summarize the current knowledge about the present estimates of the prevalence of comorbid sleep disorders in CP patients, sleep detection methods, sleep characterization in CP, and the effect of sleep disorders on CP and current therapies. We also summarize current knowledge of the neurochemical mechanisms of CP comorbidity with sleep disorders. In conclusion, insufficient attention has been paid to the role of sleep disorders in CP patients, and CP patients should be screened for sleep disorders in the clinic. Special attention should be given to a possible risk of drug-drug interaction when using two types of drugs targeting pain and sleep simultaneously. The current insight into the neurobiological mechanisms underlying CP comorbidity with sleep disorders is still rather limited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.