Evidence map›Paper›PMID 37324739›Full record

ReviewFrontiers in nutrition2023

Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection.

Arianna Romani, Domenico Sergi, Enrico Zauli, Rebecca Voltan, Giada Lodi, Mauro Vaccarezza, Lorenzo Caruso, Maurizio Previati, Giorgio Zauli

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Arianna RomaniDepartment of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy.
Domenico SergiDepartment of Translational Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.
Enrico ZauliDepartment of Translational Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.
Rebecca VoltanDepartment of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy.
Giada LodiDepartment of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy.
Mauro VaccarezzaCurtin Medical School & Curtin Health Innovation Research Institute (CHIRI), Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
Lorenzo CarusoDepartment of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy.
Maurizio PreviatiDepartment of Translational Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.
Giorgio ZauliResearch Department, King Khaled Eye Specialistic Hospital, Riyadh, Saudi Arabia.
University of Ferrara · ITCurtin University · AUKing Khaled Eye Specialist Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 outbreak has infected a vast population across the world, causing more than 664 million cases and 6.7 million deaths by January 2023. Vaccination has been effective in reducing the most critical aftermath of this infection, but some issues are still present regarding re-infection prevention, effectiveness against variants, vaccine hesitancy and worldwide accessibility. Moreover, although several old and new antiviral drugs have been tested, we still lack robust and specific treatment modalities. It appears of utmost importance, facing this continuously growing pandemic, to focus on alternative practices grounded on firm scientific bases. In this article, we aim to outline a rigorous scientific background and propose complementary nutritional tools useful toward containment, and ultimately control, of SARS-CoV-2 infection. In particular, we review the mechanisms of viral entry and discuss the role of polyunsaturated fatty acids derived from α-linolenic acid and other nutrients in preventing the interaction of SARS-CoV-2 with its entry gateways. In a similar way, we analyze in detail the role of herbal-derived pharmacological compounds and specific microbial strains or microbial-derived polypeptides in the prevention of SARS-CoV-2 entry. In addition, we highlight the role of probiotics, nutrients and herbal-derived compounds in stimulating the immunity response.

Indexed as

ACE-2COVID-19natural productsphytochemicalsSARS-CoV-2TMPRSS2

Identifiers

PMID37324739
PMCPMC10267353
OpenAlexW4379056152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.