ReviewFrontiers in cardiovascular medicine2023
Ventriculo-arterial (un)coupling in septic shock: Impact of current and upcoming hemodynamic drugs.
Review in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06853574 (Changes in Ventriculo-arterial Coupling and Myocardial Work During Treatment of Sepsis and Septic Shock), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Changes in Ventriculo-arterial Coupling and Myocardial Work During Treatment of Sepsis and Septic Shock: a Prospective Interventional Study
Who cites it
12 citing papers in PubMed, 9 citations in OpenAlex.
- Evaluating Multiple Treatments and Strategies for Sepsis in Adaptive Platform (EURASSIA) trial in Japan: a core protocol.BMJ open · 2026Article
- Sex differences in vascular function among individuals with heart failure: a systematic review.International journal of cardiology. Heart & vasculature · 2026Review
- Developing a comprehensive haemodynamic ultrasound assessment for critical care: Rationale and methodology from the FUSIC programme.Journal of the Intensive Care Society · 2026Article
- The usual suspects: a pragmatic framework to identify and address reversible contributors in apparent refractory septic shock.Critical care (London, England) · 2026Review
- Review
- A pilot study of the effect of norepinephrine dose on left ventricular-arterial coupling in patients with septic shock.Scientific reports · 2026Article
- Ea/Ees and oscillatory power fraction capture complementary but distinct components of ventriculoarterial coupling: a porcine study.Frontiers in physiology · 2026Article
- ECMO in Refractory Septic Shock: Patient Selection, Timing and Hemodynamic Targets.Journal of clinical medicine · 2025Review
- U-shaped prognostic value of left ventricular-arterial coupling in septic patients: a prospective study.European journal of medical research · 2024Article
- Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock.Intensive care medicine experimental · 2024Article
- Commentary: Ventriculo-arterial (un)coupling in septic shock: impact of current and upcoming hemodynamic drugs.Frontiers in cardiovascular medicine · 2023Article
- Distributive shock in cardiac intensive care unit patients.Indian heart journalReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is an archetype of distributive shock and combines different levels of alterations in preload, afterload, and often cardiac contractility. The use of hemodynamic drugs has evolved over the past few years, along with the invasive and non-invasive tools used to measure these components in real time. However, none of them is impeccable, which is why the mortality of septic shock remains too high. The concept of ventriculo-arterial coupling (VAC) allows for the integration of these three fundamental macroscopic hemodynamic components. In this mini review, we discuss the knowledge, tools, and limitations of VAC measurement, along with the evidence supporting ventriculo-arterial uncoupling in septic shock. Finally, the impact of recommended hemodynamic drugs and molecules on VAC is detailed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.