Evidence map›Paper›PMID 37324493›Full record

ArticleFrontiers in pharmacology2023

Safety and effectiveness of the combination of remimazolam tosilate and propofol in gastroscopy: a multicenter, randomized controlled, single-blind clinical trial.

Chunyan Wang, Yangzheng Gao, Jie Li, Linlin Zhang, Qing Li, Yize Li, Yuechun Lu, Jiangang Sun, Yang Zhang, Yaobei Cheng and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Chunyan WangDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Yangzheng GaoDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Jie LiDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Linlin ZhangDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Qing LiDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Yize LiDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Yuechun LuDepartment of Anesthesiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Jiangang SunDepartment of Anesthesiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yang ZhangTianjin Fourth Central Hospital, Tianjin, China.
Yaobei ChengTianjin Jinghai Hospital, Tianjin, China.
Shidong ZhangTianjin Jinghai Hospital, Tianjin, China.
Guolin WangDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Yonghao YuDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Tianjin Medical University General Hospital · CNTianjin Hospital · CNSecond Hospital of Tianjin Medical University · CNTianjin Fourth Central Hospital · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remimazolam tosilate (RT) is a new short-acting γ-aminobutyric acid A (GABAA) receptors agonist. However, its optimal use mode and dosage still remain unclear. This study aimed to examine the safety and effectiveness of the combination of RT and propofol in gastroscopy. This was a prospective, single-blind, randomized, multicenter, parallel-group study. All eligible 256 patients were randomized into the following 3 groups. Patients were anesthetized with propofol (Group P), RT (Group R) or the combination of RT and propofol (Group RP). The primary efficacy endpoints were: body movement score; satisfaction of gastroscopy doctors; success rate of sedation and effects on sleep status. Sedation induction time, time to be fully alert and adverse events were also recorded. The probability of complete immobility was lower in group R (33.73%) than in group P (86.67%) and RP (83.13%). The rate of doctors' satisfaction was much lower in group R (28.92%) than in group P (77.78%) and RP (72.29%). The success rate of sedation and sleep outcome score has no difference in the three groups. The time to adequate sedation was longer in group RP (77.27 ± 18.63 s) than in group P (64.47 ± 24.36 s), but much shorter than that in group R (102.84 ± 46.43s). The time to be fully alert was shorter in group R (6.30 ± 1.52 min) and RP (6.54 ± 1.13 min) than in group P (7.87 ± 1.08 min). The proportion of sedative hypotension was significantly higher in group P (41.11%) than in group R (1.20%) and group RP (3.61%) (

Indexed as

adverse eventsbenzodiazepine (BZD)endoscopic sedationgastroscopypropofolremimazolam tosilate

Identifiers

PMID37324493
PMCPMC10264591
OpenAlexW4378905293

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.