Evidence map›Paper›PMID 37324400›Full record

ArticleFrontiers in physiology2023

Ayyagari Ramlal, Isha Bhat, Aparna Nautiyal, Pooja Baweja, Sahil Mehta, Vikash Kumar, Shikha Tripathi, Rohit Kumar Mahto, Manisha Saini, Bingi Pujari Mallikarjuna and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Ayyagari RamlalDivision of Genetics, ICAR-Indian Agricultural Research Institute (IARI), Pusa Campus, New Delhi, India.
Isha BhatDepartment of Biosciences, Jamia Millia Islamia, New Delhi, Delhi, India.
Aparna NautiyalDepartment of Botany, Deshbandhu College, University of Delhi, New Delhi, India.
Pooja BawejaDepartment of Botany, Maitreyi College, University of Delhi, New Delhi, India.
Sahil MehtaDepartment of Botany, Hansraj College, University of Delhi, New Delhi, India.
Vikash KumarFaculty of Agricultural Sciences, Institute of Applied Sciences and Humanities, GLA University, Mathura, Uttar Pradesh, India.
Shikha TripathiICAR- National Institute for Biotechnology, New Delhi, India.
Rohit Kumar MahtoDivision of Genetics, ICAR-Indian Agricultural Research Institute (IARI), Pusa Campus, New Delhi, India.
Manisha SainiDivision of Genetics, ICAR-Indian Agricultural Research Institute (IARI), Pusa Campus, New Delhi, India.
Bingi Pujari MallikarjunaDivision of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), Regional Research Centre, Dharwad, Karnataka, India.
Shukla SalujaDepartment of Botany, Sri Venkateswara College, University of Delhi, New Delhi, India.
S K LalDivision of Genetics, ICAR-Indian Agricultural Research Institute (IARI), Pusa Campus, New Delhi, India.
Sreeramanan SubramaniamSchool of Biological Sciences, Universiti Sains Malaysia (USM), Georgetown, Penang, Malaysia.
Iten M FawzyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt.
Ambika RajendranDivision of Genetics, ICAR-Indian Agricultural Research Institute (IARI), Pusa Campus, New Delhi, India.
Indian Agricultural Research Institute · INUniversity of Delhi · INFuture University in Egypt · EGGLA University · INJamia Millia Islamia · INNational Research Centre on Plant Biotechnology · INUniversiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are one of the major reasons for deaths globally. The renin-angiotensin-aldosterone system (RAAS) regulates body hypertension and fluid balance which causes CVD. Angiotensin-converting enzyme I (ACE I) is the central Zn-metallopeptidase component of the RAAS playing a crucial role in maintaining homeostasis of the cardiovascular system. The available drugs to treat CVD have many side effects, and thus, there is a need to explore phytocompounds and peptides to be utilized as alternative therapies. Soybean is a unique legume cum oilseed crop with an enriched source of proteins. Soybean extracts serve as a primary ingredient in many drug formulations against diabetes, obesity, and spinal cord-related disorders. Soy proteins and their products act against ACE I which may provide a new scope for the identification of potential scaffolds that can help in the design of safer and natural cardiovascular therapies. In this study, the molecular basis for selective inhibition of 34 soy phytomolecules (especially of beta-sitosterol, soyasaponin I, soyasaponin II, soyasaponin II methyl ester, dehydrosoyasaponin I, and phytic acid) was evaluated using

Indexed as

angiotensin-converting enzyme Ibeta-sitosterolcardiovascular diseasesnatural drugsphytic acidphytocompoundsrenin–angiotensin–aldosterone systemsoybean

Identifiers

PMID37324400
PMCPMC10264776
OpenAlexW4378903132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.