Evidence map›Paper›PMID 37324244›Full record

ArticleBrain communications2023

Clinical impact of anti-inflammatory microglia and macrophage phenotypes at glioblastoma margins.

Imran Noorani, Kastytis Sidlauskas, Sean Pellow, Reece Savage, Jeannette L Norman, David S Chatelet, Mark Fabian, Paul Grundy, Jeng Ching, James A R Nicoll and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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  14. Multiomics insights into BMI-related intratumoral microbiota in gastric cancer.Frontiers in cellular and infection microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Imran NooraniDepartment of Neuromuscular Diseases, The Francis Crick Institute and University College London, London NW1 1AT, UK.ORCID https://orcid.org/0000-0003-4289-2345
Kastytis SidlauskasClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Sean PellowClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Reece SavageClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Jeannette L NormanHistochemistry Research Unit, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
David S ChateletBiomedical Imaging Unit, Southampton General Hospital, University of Southampton, Southampton, UK.
Mark FabianDepartment of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Paul GrundyDepartment of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Jeng ChingDepartment of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
James A R NicollClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Delphine BocheClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-5884-130X
University Hospital Southampton NHS Foundation Trust · GBUniversity of Southampton · GBQueen Mary University of London · GBSouthampton General Hospital · GBThe Francis Crick Institute · GB

Funding

Cancer Research UK FC001169Cancer Research UK TICCPP-2022/100004Wellcome Trust FC001169
6 · The paper itself

Abstract

Glioblastoma is a devastating brain cancer for which effective treatments are required. Tumour-associated microglia and macrophages promote glioblastoma growth in an immune-suppressed microenvironment. Most recurrences occur at the invasive margin of the surrounding brain, yet the relationships between microglia/macrophage phenotypes, T cells and programmed death-ligand 1 (an immune checkpoint) across human glioblastoma regions are understudied. In this study, we performed a quantitative immunohistochemical analysis of 15 markers of microglia/macrophage phenotypes (including anti-inflammatory markers triggering receptor expressed on myeloid cells 2 and CD163, and the low-affinity-activating receptor CD32a), T cells, natural killer cells and programmed death-ligand 1, in 59 human

Indexed as

glioblastomaimmunotherapyintratumoural heterogeneitymacrophagemicroglia

Identifiers

PMID37324244
PMCPMC10265726
OpenAlexW4379958528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.