Evidence map›Paper›PMID 37324076›Full record

ArticleJournal of thoracic disease2023

Treatment of rheumatoid arthritis-associated interstitial lung disease in a multi-center registry cohort.

Veronica Marcoux, Stacey Lok, Prosanta Mondal, Deborah Assayag, Jolene H Fisher, Shane Shapera, Julie Morisset, Hélène Manganas, Charlene D Fell, Nathan Hambly and 10 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of thoracic disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. The prevalence of interstitial lung disease and bronchiectasis in rheumatoid arthritis: A systematic review and meta-analysis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  2. Rheumatoid Lung Disease.Mediterranean journal of rheumatology · 2025
    Review
  3. Review
  4. Treating connective tissue disease-associated interstitial lung disease - think outside the box: a perspective.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 1 country.

Veronica MarcouxDepartment of Medicine, University of Saskatchewan, Saskatoon, Canada.
Stacey LokDepartment of Medicine, University of Saskatchewan, Saskatoon, Canada.
Prosanta MondalDepartment of Community Health & Epidemiology, University of Saskatchewan, Saskatoon, Canada.
Deborah AssayagDepartment of Medicine, McGill University, Montreal, Canada.
Jolene H FisherDepartment of Medicine, University of Toronto, Toronto, Canada.
Shane ShaperaDepartment of Medicine, University of Toronto, Toronto, Canada.
Julie MorissetDepartment of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
Hélène ManganasDepartment of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
Charlene D FellDepartment of Medicine, University of Calgary, Calgary, Canada.
Nathan HamblyDepartment of Medicine, McMaster University, Hamilton, Canada.
P Gerard CoxDepartment of Medicine, McMaster University, Hamilton, Canada.
Martin KolbDepartment of Medicine, McMaster University, Hamilton, Canada.
Andrea S GershonDepartment of Medicine, University of Toronto, Toronto, Canada.
Teresa ToDalla Lana School of Public Health, University of Toronto, Canada.
Mohsen SadatsafaviCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
Nasreen KhalilCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
Alyson W WongCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
Pierce G WilcoxCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
Christopher J RyersonCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
Kerri A JohannsonDepartment of Medicine, University of Calgary, Calgary, Canada.
University of Saskatchewan · CASt. Paul's Hospital · CAMcMaster University · CAUniversity of Toronto · CACentre Hospitalier de l’Université de Montréal · CAMcGill University · CAPublic Health Ontario · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is challenging to manage, with a paucity of robust data to guide treatment. Our aim was to characterize the pharmacologic treatment of RA-ILD utilizing a retrospective design in a national multi-center prospective cohort, and to identify associations between treatment and change in lung function and survival. Methods: Patients with RA-ILD and a radiological pattern of non-specific interstitial pneumonia (NSIP) or usual interstitial pneumonia (UIP) were included. Unadjusted and adjusted linear mixed models and Cox proportional hazards models were used to compare lung function change and risk of death or lung transplant by radiologic patterns and treatment. Results: Of 161 patients with RA-ILD, UIP pattern was more common than NSIP (55.9% Conclusions: Treatment of RA-ILD is heterogeneous, with most patients in this cohort not receiving treatment. Patients with UIP had worse outcomes compared to NSIP, similar to other cohorts. Randomized clinical trials are needed to inform pharmacologic therapy in this patient population.

Indexed as

Connective tissue diseasediffuse parenchymal lung diseaselung functionoutcomespulmonary fibrosis

Identifiers

PMID37324076
PMCPMC10267945
OpenAlexW4376612464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.