Evidence map›Paper›PMID 37323619›Full record

ArticleExploration (Beijing, China)2023

Ultrasmall iron-gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET/MR imaging-guided ischemia stroke therapy.

Yujing Du, Yan Huo, Qi Yang, Zhihui Han, Linqian Hou, Bixiao Cui, Kevin Fan, Yongkang Qiu, Zhao Chen, Wenpeng Huang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Exploration (Beijing, China), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Yujing DuDepartment of Nuclear Medicine Peking University First Hospital Beijing China.
Yan HuoDepartment of Nuclear Medicine Peking University First Hospital Beijing China.
Qi YangDepartment of Nuclear Medicine Peking University First Hospital Beijing China.
Zhihui HanInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Jiangsu China.
Linqian HouInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Jiangsu China.
Bixiao CuiDepartment of Radiology and Nuclear Medicine Xuanwu Hospital Capital Medical University Beijing China.
Kevin FanDepartments of Radiology and Medical Physics University of Wisconsin-Madison Wisconsin USA.
Yongkang QiuDepartment of Nuclear Medicine Peking University First Hospital Beijing China.
Zhao ChenDepartment of Nuclear Medicine Peking University First Hospital Beijing China.
Wenpeng HuangDepartment of Nuclear Medicine Peking University First Hospital Beijing China.
Jie LuDepartment of Radiology and Nuclear Medicine Xuanwu Hospital Capital Medical University Beijing China.
Liang ChengInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Jiangsu China.ORCID https://orcid.org/0000-0001-5324-9094
Weibo CaiDepartments of Radiology and Medical Physics University of Wisconsin-Madison Wisconsin USA.ORCID https://orcid.org/0000-0003-4641-0833
Lei KangDepartment of Nuclear Medicine Peking University First Hospital Beijing China.
Peking University · CNSoochow University · CNCapital Medical University · CNUniversity of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206
6 · The paper itself

Abstract

Oxidative stress from reactive oxygen species (ROS) is a reperfusion injury factor that can lead to cell damage and death. Here, ultrasmall iron-gallic acid coordination polymer nanodots (Fe-GA CPNs) were developed as antioxidative neuroprotectors for ischemia stroke therapy guided by PET/MR imaging. As proven by the electron spin resonance spectrum, the ultrasmall Fe-GA CPNs with ultrasmall size, scavenged ROS efficiently. In vitro experiments revealed that Fe-GA CPNs could protect cell viability after being treated with hydrogen peroxide (H

Indexed as

iron‐gallic acid coordination polymer nanodotsischemic/reperfusion injuryreactive oxygen species scavenging

Identifiers

PMID37323619
PMCPMC10190924
OpenAlexW4319834276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.