Evidence map›Paper›PMID 37323542›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2023

Myeloid-Specific SIRT6 Deletion Protects Against Particulate Matter (PM

Shaopeng Chen, Mindan Wu, Zhilin Xiong, Jiewen Huang, Yingying Lv, Yuyan Li, Minjuan Zeng, Tianwen Lai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shaopeng Chen *Institute of Respiratory Diseases, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, People's Republic of China.
Mindan Wu *Department of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, People's Republic of China.
Zhilin Xiong *Institute of Respiratory Diseases, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, People's Republic of China.
Jiewen HuangInstitute of Respiratory Diseases, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, People's Republic of China.
Yingying LvInstitute of Respiratory Diseases, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, People's Republic of China.
Yuyan LiDepartment of Pulmonary and Critical Care Medicine, Dongguan Hospital of Southern Medical University, Dongguan, People's Republic of China.ORCID 0000-0003-0062-879X
Minjuan ZengLaboratory Animal Center, Guangdong Medical University, Zhanjiang, People's Republic of China.
Tianwen LaiInstitute of Respiratory Diseases, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, People's Republic of China.ORCID 0000-0001-9921-3425
Guangdong Medical College · CNDongguan People’s Hospital · CNShantou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Particulate matter (PM Methods: The effect of SIRT6 on PM Results: PM2.5 increased SIRT6 expression in THP1 cells, but SIRT6 gene silencing decreased PM2.5 induced inflammatory cytokines in THP1 cells. Moreover, the expression of SIRT6 and inflammatory cytokines was also decreased in BMDMs with myeloid-specific deletion of SIRT6 after stimulation of PM Conclusion: Our results revealed that SIRT6 promotes the PM

Indexed as

Pulmonary Disease, Chronic ObstructiveSirtuinsAnimalsCytokinesInflammationMiceParticulate MatterCytokinesParticulate MatterSirt6 protein, mouseSirtuinslung inflammationmacrophageparticulate matterSIRT6

Identifiers

PMID37323542
PMCPMC10266380
OpenAlexW4380204208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.