ArticleFrontiers in aging2023
Quantitative nanohistology of aging dermal collagen.
Article in Frontiers in aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Effectiveness of Body Remodeling and Cellulite Appearance Improvement Treatments in the Thighs Using Symmed Radiofrequency Device.Journal of cosmetic dermatology · 2025Trial
- Label-free differentiation of classical and hypermobile Ehlers-Danlos syndromes using Mueller matrix polarimetry.Biophotonics discovery · 2026Article
- The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies.Mini reviews in medicinal chemistry · 2026Review
- The Impact of Ageing on Fibrillar Collagens.Sub-cellular biochemistry · 2026Review
- Collagen Hybridizing Peptides Promote Collagen Fibril GrowthACS applied bio materials · 2025Article
- Effects of Ionizing Radiation on the Biophysical Properties of Type I Collagen Fibrils.PloS one · 2025Article
- Investigation of dermal collagen nanostructures in Ehlers-Danlos Syndrome (EDS) patients.PloS one · 2024Article
- Development of a facile method to compute collagen network pathological anisotropy using AFM imaging.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin is the largest organ in the body and is essential for protecting us from environmental stressors such as UV radiation, pollution, and pathogens. As we age, our skin undergoes complex changes that can affect its function, appearance, and health. These changes result from intrinsic (chronological) and extrinsic (environmental) factors that can cause damage to the skin's cells and extracellular matrix. As higher-resolution microscopical techniques, such as Atomic Force Microscopy (AFM), are being deployed to support histology, it is possible to explore the biophysical properties of the dermal scaffold's constituents, such as the collagen network. In this study, we demonstrate the use of our AFM-based quantitative nanohistology, performed directly on unfixed cryosections of 30 donors (female, Caucasian), to differentiate between dermal collagen from different age groups and anatomical sites. The initial 420 (10 × 10 μm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.