Evidence map›Paper›PMID 37323311›Full record

ArticleCureus2023

Identification of Genomic Alterations in Thai Patients With Colorectal Cancer Using Next-Generation Sequencing-Based Multigene Cancer Panel.

Worapoj Jinda, Hathaiwan Moungthard, Chanin Limwongse, Manop Pithukpakorn, Pensri Saelee, Nareerat Pokkasup, Saipan Khunpukdee, Suchitraporn Sukthaworn, Jaruphan Jumpasri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Worapoj JindaDivision of Research and Technology Assessment, National Cancer Institute, Bangkok, THA.
Hathaiwan MoungthardDivision of Gastrointestinal and Liver Clinic, National Cancer Institute, Bangkok, THA.
Chanin LimwongseDivision of Medical Genetics, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, THA.
Manop PithukpakornDivision of Medical Genetics, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, THA.
Pensri SaeleeDivision of Research and Technology Assessment, National Cancer Institute, Bangkok, THA.
Nareerat PokkasupDivision of Gastrointestinal and Liver Clinic, National Cancer Institute, Bangkok, THA.
Saipan KhunpukdeeDivision of Gastrointestinal and Liver Clinic, National Cancer Institute, Bangkok, THA.
Suchitraporn SukthawornDivision of Research and Technology Assessment, National Cancer Institute, Bangkok, THA.
Jaruphan JumpasriDivision of Policy and Medical Strategy Development, National Cancer Institute, Bangkok, THA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Colorectal cancer (CRC) is one of the leading causes of death and illness in the general population. Although the incidence of CRC is steadily decreasing worldwide, it is being diagnosed more in individuals under 50 years of age. Multiple disease-causing variants have been reported to be involved in the development of CRC. This study aimed to investigate the molecular and clinical characteristics of Thai patients with CRC. Methods NGS-based multigene cancer panel testing was performed on 21 unrelated patients. Target enrichment was performed using a custom-designed Ion AmpliSeq on-demand panel. Thirty-six genes associated with CRC and other cancer were analyzed for variant detection. Results Sixteen variants (five nonsense, eight missense, two deletions, and one duplication) in nine genes were identified in 12 patients. Eight (66.7%) patients harboring disease-causing deleterious variants in genes

Indexed as

cancer susceptibility genescolorectal cancermultigene cancer panelnext generation sequencingpathogenic gene

Identifiers

PMID37323311
PMCPMC10267666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.