Evidence map›Paper›PMID 37322823›Full record

ArticleJournal of diabetes investigation2023

A case of fulminant type 1 diabetes and protein C deficiency complicated by deep vein thrombosis.

Masato Kohata, Shinjiro Kodama, Nobuhiro Yaoita, Shinichiro Hosaka, Kei Takahashi, Keizo Kaneko, Junta Imai, Satoshi Yasuda, Hideki Katagiri

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Masato KohataDepartment of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan.
Shinjiro KodamaDepartment of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan.
Nobuhiro YaoitaDepartment of Cardiovascular Medicine, Tohoku University Hospital, Sendai, Japan.
Shinichiro HosakaDepartment of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan.
Kei TakahashiDepartment of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan.
Keizo KanekoDepartment of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan.
Junta ImaiDepartment of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan.ORCID https://orcid.org/0000-0003-4636-5905
Satoshi YasudaDepartment of Cardiovascular Medicine, Tohoku University Hospital, Sendai, Japan.
Hideki KatagiriDepartment of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan.ORCID https://orcid.org/0000-0003-1093-3704
Tohoku University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 25-year-old man was diagnosed with diabetic ketoacidosis (DKA) at the onset of fulminant type 1 diabetes. After acute-phase DKA treatment including placement of a central venous catheter, a massive deep vein thrombosis (DVT) and pulmonary embolism (PE) were detected on hospital day 15. His protein C (PC) activity and antigen levels were low even 33 days after completing the DKA treatment, indicating partial type I PC deficiency. Severe PC dysfunction, due to overlapping of partial PC deficiency and hyperglycemia-induced PC suppression, concomitant with dehydration and catheter treatment, may have induced the massive DVT with PE. This case suggests that anti-coagulation therapy should be combined with acute-phase DKA treatment in patients with PC deficiency, even those who have been asymptomatic. As patients with partial PC deficiency should perhaps be included among those with severe DVT complications of DKA, venous thrombosis should always be considered as a potential complication of DKA.

Indexed as

Diabetes Mellitus, Type 1Diabetic KetoacidosisProtein C DeficiencyPulmonary EmbolismVenous ThrombosisAdultHumansMaleRisk FactorsDeep vein thrombosisDiabetic ketoacidosisProtein C

Identifiers

PMID37322823
PMCPMC10360373
OpenAlexW4380871401

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.