Evidence map›Paper›PMID 37322383›Full record

ArticleJournal of chemical ecology2023

Characterization of Arthropeptide B, an Antifungal Cyclic Tetrapeptide from Arthrobacter humicola.

Juan Sebastian Gomez, Michael Shaikhet, A Kiripuvaney Loganathan, Michael G Darnowski, Christopher N Boddy, David R McMullin, Tyler J Avis

Abstract read
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In one paragraph

Article in Journal of chemical ecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Juan Sebastian GomezDepartment of Chemistry, Carleton University, Ottawa, ON, K1S 5B6, Canada.
Michael ShaikhetInstitute of Biochemistry, Carleton University, Ottawa, ON, K1S 5B6, Canada.
A Kiripuvaney LoganathanDepartment of Chemistry, Carleton University, Ottawa, ON, K1S 5B6, Canada.
Michael G DarnowskiDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Christopher N BoddyDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
David R McMullinDepartment of Chemistry, Carleton University, Ottawa, ON, K1S 5B6, Canada.
Tyler J AvisDepartment of Chemistry, Carleton University, Ottawa, ON, K1S 5B6, Canada. tyler.avis@carleton.ca.
Carleton University · CAUniversity of Ottawa · CA

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2020-06406
6 · The paper itself

Abstract

Disease suppressive composts are known, yet little information on the potential role of specific microbial antagonist within are available. Arthrobacter humicola isolate M9-1A has been obtained from a compost prepared from marine residues and peat moss. The bacterium is a non-filamentous actinomycete with antagonistic activity against plant pathogenic fungi and oomycetes sharing its ecological niche in agri-food microecosystems. Our objective was to identify and characterize compounds with antifungal activity produced by A. humicola M9-1A. Arthrobacter humicola culture filtrates were tested for antifungal activity in vitro and in vivo and a bioassay-guided approach was used to identify potential chemical determinants of its observed activity against molds. The filtrates reduced the development of lesions of Alternaria rot on tomatoes and the ethyl acetate extract inhibited growth of Alternaria alternata. A compound, arthropeptide B [cyclo-(L-Leu, L-Phe, L-Ala, L-Tyr)], was purified from the ethyl acetate extract of the bacterium. Arthropeptide B is a new chemical structure reported for the first time and has shown antifungal activity against A. alternata spore germination and mycelial growth.

Indexed as

Antifungal AgentsArthrobacterAcetatesAlternariaPlantsAcetatesAntifungal Agentsethyl acetateAntifungalArthrobacter humicolaBioactive compoundsBiocontrolCyclic peptide

Identifiers

PMID37322383
OpenAlexW4380738727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.