ArticleNature microbiology2023
Streptomyces polyketides mediate bacteria-fungi interactions across soil environments.
Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Spatial Variation in Mycosphere Soil Bacterial Communities ofMicroorganisms · 2026Article
- γ-Butyrolactones and γ-butenolides as autoregulatory systems: key mediators of intraspecific, interspecific, and interkingdom communication in Streptomyces.Archives of microbiology · 2026Review
- Unlocking the Bioactive Potential of Streptomyces: A Multidisciplinary Approach to Strain Improvement.MicrobiologyOpen · 2026Review
- Bioprospecting Indoor Bacteria Producing Bioactive Metabolites.Environmental microbiology reports · 2026Article
- Draft genome of novel Streptomyces sp. strain JW3 selected for its inhibition of other Streptomyces spp.BMC genomic data · 2026Article
- Confrontations betweenApplied and environmental microbiology · 2026Article
- Multi-omics analysis of interspecies interactions in a soil Streptomyces community provides functional insights into siderophore ecology.Scientific reports · 2026Article
- The role of Bacterial-Fungal interactions in cigar tobacco fermentation: insights from community dynamics and physicochemical correlations.BMC microbiology · 2026Article
- Biodiversity-Driven Natural Products and Bioactive Metabolites.Plants (Basel, Switzerland) · 2025Review
- Mechanism ofApplied and environmental microbiology · 2025Article
- Phenazines contribute to microbiome dynamics by targeting topoisomerase IV.Nature microbiology · 2025Article
- Whole-chromosome duplications drive antimicrobial resistance inbioRxiv : the preprint server for biology · 2025Article
- Article
- Identification of a fungal antibacterial endopeptidase that cleaves peptidoglycan.EMBO reports · 2025Article
- Genomic insights reveal community structure and phylogenetic associations of endohyphal bacteria and viruses in fungal endophytes.Environmental microbiome · 2025Article
- Confrontations of the Pathogenic Fungus Colletotrichum graminicola With a Biocontrol Bacterium or a Ubiquitous Fungus Trigger Synthesis of Secondary Metabolites With Lead Structures of Synthetic Fungicides.Environmental microbiology · 2025Article
- Lydicamycins induce morphological differentiation in actinobacterial interactions.Applied and environmental microbiology · 2025Article
- Interactions with native microbial keystone taxa enhance the biocontrol efficiency of Streptomyces.Microbiome · 2025Article
- Application of microbial pigments in the pharmaceutical industry: current status and opportunities.Archives of microbiology · 2025Review
- Metabarcoding expands knowledge on diversity and ecology of rare actinobacteria in the Brazilian Cerrado.Folia microbiologica · 2025Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the interaction between prokaryotic and eukaryotic microorganisms is crucial for the functioning of ecosystems, information about the processes driving microbial interactions within communities remains scarce. Here we show that arginine-derived polyketides (arginoketides) produced by Streptomyces species mediate cross-kingdom microbial interactions with fungi of the genera Aspergillus and Penicillium, and trigger the production of natural products. Arginoketides can be cyclic or linear, and a prominent example is azalomycin F produced by Streptomyces iranensis, which induces the cryptic orsellinic acid gene cluster in Aspergillus nidulans. Bacteria that synthesize arginoketides and fungi that decode and respond to this signal were co-isolated from the same soil sample. Genome analyses and a literature search indicate that arginoketide producers are found worldwide. Because, in addition to their direct impact, arginoketides induce a secondary wave of fungal natural products, they probably contribute to the wider structure and functioning of entire soil microbial communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.