ArticleScientific reports2023
Metabolic engineering of Halomonas campaniensis strain XH26 to remove competing pathways to enhance ectoine production.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Exploring Ectoine Production From Methanol, Formate, and Electrochemically Produced Formate byEngineering in life sciences · 2026Article
- Establishing a reference cultivation protocol for systematic characterisation of theFrontiers in bioengineering and biotechnology · 2026Article
- Metabolic response ofFrontiers in microbiology · 2026Article
- Developing High-Efficiency Electroporation Protocols for Hard-To-Transform Halomonas spp.Microbial biotechnology · 2025Article
- Establishing Halomonas as a chassis for industrial biotechnology: advances in synthetic biology tool development and metabolic engineering strategies.Microbial cell factories · 2025Review
- Metabolic engineering of Bacillus licheniformis DW2 for ectoine production.World journal of microbiology & biotechnology · 2025Article
- Halomonas flagellata sp. nov., a halophilic bacterium isolated from saline soil in Xinjiang.Archives of microbiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectoine has gained considerable attention as a high-value chemical with significant application potential and market demand. This study aimed to increase ectoine yields by blocking the metabolic shunt pathway of L-aspartate-4-semialdehyde, the precursor substrate in ectoine synthesis. The homoserine dehydrogenase encoded by hom in H. campaniensis strain XH26 is responsible for the metabolic shunt of L-aspartate-4-semialdehyde to glycine. CRISPR/Cas9 technology was used to seamlessly knockout hom, blocking the metabolic shunt pathway to increase ectoine yields. The ectoine yield of XH26/Δhom was 351.13 mg (g CDW)
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Registered trials
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