ArticleMolecular psychiatry2023
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression.
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Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EANM perspective on clinical PET and SPECT imaging in schizophrenia-spectrum disorders: a systematic review of longitudinal studies.European journal of nuclear medicine and molecular imaging · 2025Pooled it
- Single ayahuasca administration mitigates long-term behavioral and neurochemical effects of early-life stress in rats.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- taVNS alleviates depressive-like and metabolic dysfunction in T2DD mice with modulation of hypothalamic 5-HT signaling.Translational psychiatry · 2026Article
- Neural signaling mechanisms in depression: bridging classical monoamine hypotheses, animal models, and emerging antidepressant strategies.Frontiers in cell and developmental biology · 2026Review
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Real-World Assessment of Transcranial Direct Current Stimulation (tDCS) Combined with Sertraline in the Treatment of Depression in Vietnam.Neuropsychiatric disease and treatment · 2026Article
- Updated Freudian drive theory: childhood trauma, epigenetics, serotonin and beta endorphin.Frontiers in psychiatry · 2026Article
- A unified model library maps how neuromodulation reshapes the excitability landscape of neurons across the brain.PLoS computational biology · 2025Article
- Integrating cellular and soluble immune signatures of major depression with and without recent suicide attempts.Translational psychiatry · 2025Article
- Review
- A history of metaphorical brain talk in psychiatry.Molecular psychiatry · 2025Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Functional Diversity of Serotonin Neurons in the Dorsal and Median Raphe Nuclei in Emotional Responses.Neuropsychopharmacology reports · 2025Review
- From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025Review
- Major depressive disorder on a neuromorphic continuum.Nature communications · 2025Article
- [Mechanisms of action of antidepressive pharmacotherapy: brain and mind-body and environment].Der Nervenarzt · 2025Review
- Examining memory reconsolidation as a mechanism of nitrous oxide's antidepressant action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Review
- Insights from a methylome-wide association study of antidepressant exposure.Nature communications · 2025Article
- An Updated Bio-Behavioral Profile of the Flinders Sensitive Line Rat: Reviewing the Findings of the Past Decade.Pharmacology research & perspectives · 2025Review
- Dynamics of human serotonin synthesis differentially link to reward anticipation and feedback.Molecular psychiatry · 2025Article
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Authors and funding
35 authors.
Sameer JauharCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK. Sameer.jauhar@kcl.ac.uk.ORCID 0000-0002-3878-3659
Danilo ArnoneDepartment of Psychiatry and Behavioural Science, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.ORCID 0000-0003-3831-2301
David S BaldwinClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Michael BloomfieldMental Health Neuroscience, Division of Psychiatry, University College, London, UK.ORCID 0000-0002-1972-4610
Michael BrowningDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Trust, Oxford, United Kingdom.
Anthony J CleareCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.ORCID 0000-0002-6990-939X
Phillip CorlettDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06519, USA.ORCID 0000-0002-5368-1992
J F William DeakinDepartment of Psychiatry, University of Manchester, Manchester, UK.ORCID 0000-0002-2750-962X
David ErritzoeDivision of Brain Sciences, Dept of Medicine, Imperial College, London, UK.ORCID 0000-0002-7022-6211
Cynthia FuDepartment of Psychological Sciences, School of Psychology, University of East London, London, UK.ORCID 0000-0003-4313-3500
Paolo Fusar-PoliDepartment of Psychosis Studies, IoPPN, King's College, London, UK.ORCID 0000-0003-3582-6788
Guy M GoodwinDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Trust, Oxford, United Kingdom.ORCID 0000-0002-1426-2816
Joseph HayesMental Health Neuroscience, Division of Psychiatry, University College, London, UK.
Robert HowardMental Health Neuroscience, Division of Psychiatry, University College, London, UK.
Oliver D HowesDepartment of Psychosis Studies, IoPPN, King's College, London, UK.
Mario F JuruenaCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.ORCID 0000-0001-8558-3396
Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7142-4669
Stephen M LawrieDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2444-5675
Hamish McAllister-WilliamsFaculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK.
Steven MarwahaInstitute for Mental Health, University of Birmingham, Birmingham, UK.
David MatuskeyDepartments of Radiology and Biomedical Sciences, Psychiatry, and Neurology, Yale University, New Haven, CT, USA.ORCID 0000-0001-7508-6572
Robert A McCutcheonDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Trust, Oxford, United Kingdom.ORCID 0000-0003-1102-2566
David J NuttDivision of Brain Sciences, Dept of Medicine, Imperial College, London, UK.ORCID 0000-0002-1286-1401
Carmine ParianteCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.ORCID 0000-0002-9132-5091
Toby PillingerDepartment of Psychosis Studies, IoPPN, King's College, London, UK.ORCID 0000-0002-6074-2626
Rajiv RadhakrishnanYale Institute for Global Health, New Haven, CT, USA.ORCID 0000-0002-8220-655X
James RuckerCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.ORCID 0000-0003-4647-8088
Sudhakar SelvarajLouis Faillace Department of Psychiatry and Behavioral Science, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.ORCID 0000-0002-9494-172X
Paul StokesCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.
Rachel UpthegroveInstitute for Mental Health, University of Birmingham, Birmingham, UK.ORCID 0000-0001-8204-5103
Nefize YalinCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.
Lakshmi YathamDepartment of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Allan H YoungCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.ORCID 0000-0003-2291-6952
Roland ZahnCentre for Affective Disorders, Psychological Medicine, IoPPN, King's College, London, UK.
Philip J CowenDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Trust, Oxford, United Kingdom.ORCID 0000-0001-5518-6138
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTMS-EEG investigation of prefrontal cortical excitability in depression and rTMS treatment responseR21MH119441 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI MURPHY, NICHOLAS, SELVARAJ, SUDHAKAR · 2020 to 2021
$435kBrain exosome biomarker targets to optimize pharmacologic treatment of depression in pregnancyR21HD106779 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GOETZL, LAURA, MACHADO VIEIRA, RODRIGO · 2022 to 2023
$429kMedical Research Council MR/J002739/1Medical Research Council MR/S003037/1Medical Research Council MR/S037675/1NCATS NIH HHS UL1 TR001863NICHD NIH HHS R21 HD106779NIMH NIH HHS R21 MH119441Wellcome Trust
Abstract
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DepressionSerotoninSerotonin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.