ArticleNPJ Parkinson's disease2023
Focused ultrasound thalamotomy for tremor treatment impacts the cerebello-thalamo-cortical network.
Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Neuroimaging of Parkinson's Disease
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Efficacy and safety of MRI-guided focused ultrasound lesioning for tremor-dominant Parkinson Disease: A systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Efficacy and safety of magnetic resonance-guided focused ultrasound for Parkinson's disease: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.NeuroImage. Clinical · 2026Article
- A generic, rapid and robust platform for personalized functional circuit-guided neuromodulation targeting.Nature protocols · 2026Review
- Robust lesion network mapping reveals genuine symptom-specific networks.bioRxiv : the preprint server for biology · 2026Article
- Focused ultrasound thalamotomy improves voice tremor in essential tremor: objective insight from artificial intelligence.Scientific reports · 2026Article
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- Article
- Long-term outcomes after caudal zona incerta-forel field ablation: three-year clinical follow-up in advanced Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- The Results of a 12-Month Open-Label Follow-Up Study with MRI Monitoring of Patients with Parkinson's Disease After MRI-Guided FUS.Journal of clinical medicine · 2025Article
- Immediate Motor Control Enhancement via Pallidothalamic Tract (PTT) Circuit Ablation: A Dual-Target MR-Guided Focused Ultrasound Approach for Tremor-Dominant Parkinson's Disease.European journal of neurology · 2025Article
- MR-guided focused ultrasound thalamotomy in a patient with thrombocytopenia: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Magnetic Resonance-Guided Focused Ultrasound Thalamotomy in a Prospective Cohort of 52 Patients with Parkinson's Disease: A Possible Critical Role of Age and Lesion Volume for Predicting Tremor Relapse.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- The Use of Focused Ultrasound Ablation for Movement Disorders.Magnetic resonance imaging clinics of North America · 2024Review
- Early re-emerging tremor after MRgFUS thalamotomy: case-control analysis of procedural and imaging features.Frontiers in neurology · 2024Article
- Distinct medication-state modulation of motor-cortical low-beta power in tremor-dominant and postural instability/gait difficulty Parkinson's disease: a source-space resting-state EEG study.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
High-intensity Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is a recent, non-invasive line of treatment for medication-resistant tremor. We used MRgFUS to produce small lesions in the thalamic ventral intermediate nucleus (VIM), an important node in the cerebello-thalamo-cortical tremor network, in 13 patients with tremor-dominant Parkinson's disease or essential tremor. Significant tremor alleviation in the target hand ensued (t(12) = 7.21, p < 0.001, two-tailed), which was strongly associated with the functional reorganization of the brain's hand region with the cerebellum (r = 0.91, p < 0.001, one-tailed). This reorganization potentially reflected a process of normalization, as there was a trend of increase in similarity between the hand cerebellar connectivity of the patients and that of a matched, healthy control group (n = 48) after treatment. Control regions in the ventral attention, dorsal attention, default, and frontoparietal networks, in comparison, exhibited no association with tremor alleviation and no normalization. More broadly, changes in functional connectivity were observed in regions belonging to the motor, limbic, visual, and dorsal attention networks, largely overlapping with regions connected to the lesion targets. Our results indicate that MRgFUS is a highly efficient treatment for tremor, and that lesioning the VIM may result in the reorganization of the cerebello-thalamo-cortical tremor network.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.