Evidence map›Paper›PMID 37322020›Full record

ReviewNature communications2023

The intersection of undernutrition, microbiome, and child development in the first years of life.

Fanette Fontaine, Sondra Turjeman, Karel Callens, Omry Koren

Registry-linked trialAbstract readReview
In one paragraph

Review in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06447220 (Washed Microbiota Transplantation for Malnutrition), which is not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06447220 recruitingnot on this map

Washed Microbiota Transplantation for Malnutrition

TypeobservationalSponsorThe Second Hospital of Nanjing Medical UniversityRan2023 to 2031Enrolled100ConditionsMalnutritionArmswashed microbiota transplantation
3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Trial
  2. Review
  3. The gut microbiota in malnutrition.Nature reviews. Microbiology · 2026
    Review
  4. Article
  5. Clostridium Abundance and Lower Weight-for-AgeJMIR pediatrics and parenting · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. The Gut in Early Life-Postnatal Challenges.Children (Basel, Switzerland) · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Maternal group BAnnals of medicine · 2025
    Article
  17. Article
  18. Article
  19. The value of an ecological approach to address micronutrient malnutrition.The American journal of clinical nutrition · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fanette FontaineFood and Agriculture Organization of the United Nations, Rome, Italy.
Sondra TurjemanAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.ORCID 0000-0002-5224-1215
Karel CallensFood and Agriculture Organization of the United Nations, Rome, Italy.
Omry KorenAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. omry.koren@biu.ac.il.ORCID 0000-0002-7738-1337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Undernutrition affects about one out of five children worldwide. It is associated with impaired growth, neurodevelopment deficits, and increased infectious morbidity and mortality. Undernutrition, however, cannot be solely attributed to a lack of food or nutrient deficiency but rather results from a complex mix of biological and environmental factors. Recent research has shown that the gut microbiome is intimately involved in the metabolism of dietary components, in growth, in the training of the immune system, and in healthy development. In this review, we look at these features in the first three years of life, which is a critical window for both microbiome establishment and maturation and child development. We also discuss the potential of the microbiome in undernutrition interventions, which could increase efficacy and improve child health outcomes.

Indexed as

Gastrointestinal MicrobiomeMalnutritionMicrobiotaChildChild DevelopmentDietHumans

Identifiers

PMID37322020
PMCPMC10272168

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.