ArticleNature communications2023
Human orbitofrontal cortex signals decision outcomes to sensory cortex during behavioral adaptations.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Effectiveness of Pleasure Perception Training Group Therapy on Adolescents With Depression and Analysis of Factors Associated With Non-Suicidal Self-Injurious Behaviors.International journal of methods in psychiatric research · 2026Trial
- Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation.Psychopharmacology · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Placebo analgesia persistence: evaluating behavioural stability in repeated trials.Communications biology · 2026Article
- BOLD repetition enhancement in the orbitofrontal cortex during complex visuospatial processing in migraine without aura: a shift in periaqueductal gray - cortical coupling?The journal of headache and pain · 2026Article
- Morphometric Similarity Loss and Gray Matter Atrophy Align with Neurotransmitter and Mitochondrial Maps in Drug-Resistant Epilepsy.Neuropsychiatric disease and treatment · 2026Article
- Thalamic regulation of reinforcement learning strategies across prefrontal-striatal networks.Nature communications · 2025Article
- Disrupted decision making in adult male rats after prolonged withdrawal from ethanol vapor exposure.Alcohol, clinical & experimental research · 2025Article
- Predictive encoding of auditory sequences in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Dynamic reconfiguration of brain coactivation states associated with active and lecture-based learning of university physics.NPJ science of learning · 2025Article
- An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility.Science advances · 2025Article
- Multimodal Investigations of Structural and Functional Brain Alterations in Anorexia and Bulimia Nervosa and Their Relationships to Psychopathology.Biological psychiatry · 2025Article
- Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping.NeuroImage · 2025Article
- Article
- Structural Connectivity Differences Reflect Microstructural Heterogeneity of the Human Insular Cortex.Human brain mapping · 2025Article
- I fear you're getting too close: neural correlates of personal space violation in paranoia.Schizophrenia (Heidelberg, Germany) · 2025Article
- A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia.Cell reports. Medicine · 2024Article
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
- Changes in brain structure and function during early aging in patients with chronic low back pain.Frontiers in aging neuroscience · 2024Article
- Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.Neuroscience applied · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The ability to respond flexibly to an ever-changing environment relies on the orbitofrontal cortex (OFC). However, how the OFC associates sensory information with predicted outcomes to enable flexible sensory learning in humans remains elusive. Here, we combine a probabilistic tactile reversal learning task with functional magnetic resonance imaging (fMRI) to investigate how lateral OFC (lOFC) interacts with the primary somatosensory cortex (S1) to guide flexible tactile learning in humans. fMRI results reveal that lOFC and S1 exhibit distinct task-dependent engagement: while the lOFC responds transiently to unexpected outcomes immediately following reversals, S1 is persistently engaged during re-learning. Unlike the contralateral stimulus-selective S1, activity in ipsilateral S1 mirrors the outcomes of behavior during re-learning, closely related to top-down signals from lOFC. These findings suggest that lOFC contributes to teaching signals to dynamically update representations in sensory areas, which implement computations critical for adaptive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.