Evidence map›Paper›PMID 37321969›Full record

ArticleMolecular pain

BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury.

Zihan Hu, Xinren Yu, Pei Chen, Keyu Jin, Jing Zhou, Guoxiang Wang, Jiangning Yu, Tong Wu, Yulong Wang, Fuqing Lin and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Zihan HuDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.
Xinren YuDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.
Pei ChenDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.
Keyu JinDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.
Jing ZhouDepartment of Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
Guoxiang WangDepartment of Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiangning YuDepartment of Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
Tong WuDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.
Yulong WangRehabilitation Center, First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen Second People's Hospital, Shenzhen, China.
Fuqing LinDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.ORCID 0000-0002-6478-0013
Tingting ZhangDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.
Yun WangDepartment of Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China.
Xuan ZhaoDepartment of Anesthesiology, School of Medicine, Tongji University, Shanghai tenth People's Hospital, Shanghai, China.ORCID 0000-0003-4018-0360
Tongji University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical allodynia can be evoked by punctate pressure contact with the skin (punctate mechanical allodynia) and dynamic contact stimulation induced by gentle touching of the skin (dynamic mechanical allodynia). Dynamic allodynia is insensitive to morphine treatment and is transmitted through the spinal dorsal horn by a specific neuronal pathway, which is different from that for punctate allodynia, leading to difficulties in clinical treatment. K

Indexed as

HyperalgesiaSymportersAnimalsBrain-Derived Neurotrophic FactorDown-RegulationK Cl- CotransportersMiceMicrogliaSignal TransductionSpinal CordSpinal Cord Dorsal HornBrain-Derived Neurotrophic FactorK Cl- CotransportersSymportersBDNF-TrkB pathwayDynamic allodyniaKCC2microgliaspared nerve injury

Identifiers

PMID37321969
PMCPMC10402286
OpenAlexW4380854223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.