Evidence map›Paper›PMID 37321406›Full record

ArticleNeuropsychologia2023

Neuroimaging of social motivation during winning and losing: Associations with social anhedonia across the psychosis spectrum.

Amy M Jimenez, Peter E Clayson, Arpi S Hasratian, Junghee Lee, Eric A Reavis, Jonathan K Wynn, Michael F Green, William P Horan

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In one paragraph

Article in Neuropsychologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amy M JimenezDepartment of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address: amjimenez@ucla.edu.
Peter E ClaysonDepartment of Psychology, University of South Florida, Tampa, FL, USA.
Arpi S HasratianDepartment of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Junghee LeeDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Eric A ReavisDepartment of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jonathan K WynnDepartment of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Michael F GreenDepartment of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
William P HoranVeraSci, Durham, Durham, NC, USA.

Funding

Social affiliation in psychosis: Mechanisms and vulnerability factorsR01MH107422 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORAN, WILLIAM P. · 2015 to 2018
$1.9M
NIMH NIH HHS R01 MH107422
6 · The paper itself

Abstract

backgroundIndividuals with psychosis spectrum disorders (PSD) have difficulty developing social relationships. This difficulty may reflect reduced response to social feedback involving functional alterations in brain regions that support the social motivation system: ventral striatum, orbital frontal cortex, insula, dorsal anterior cingulate cortex, and amygdala. Whether these alterations span PSD is unknown.

methods71 individuals with PSD, 27 unaffected siblings, and 37 control participants completed a team-based fMRI task. After each trial, participants received performance feedback paired with the expressive face of a teammate or opponent. A 2 × 2 (win versus loss outcome x teammate versus opponent) repeated measures ANOVA by group was performed on activation in the five key regions of interest during receipt of feedback.

resultsAcross groups, three social motivation regions, ventral striatum, orbital frontal cortex, and amygdala, showed sensitivity to feedback (significant main effect of outcome), with greater activation during win versus loss trials, regardless of whether the feedback was from a teammate or opponent. In PSD, ventral striatum and orbital frontal cortex activation to win feedback was negatively correlated with social anhedonia scores.

conclusionsPatterns of neural activation during social feedback were similar in PSD, their unaffected siblings, and healthy controls. Across the psychosis spectrum, activity in key social motivation regions during social feedback was associated with individual differences in social anhedonia.

Indexed as

AnhedoniaPsychotic DisordersBrain MappingHumansMagnetic Resonance ImagingMotivationNeuroimagingRewardFunctional magnetic resonance imaging (fMRI)Psychotic disordersSchizophreniaSibling studySocial anhedoniaSocial motivationSocial rewardTeam task

Identifiers

PMID37321406
PMCPMC10527321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.