Evidence map›Paper›PMID 37321378›Full record

ArticleMagnetic resonance imaging2023

CEST2022: Amide proton transfer-weighted MRI improves the diagnostic performance of multiparametric non-contrast-enhanced MRI techniques in patients with post-treatment high-grade gliomas.

Qianqi Huang, Jingpu Wu, Nhat Le, Yiqing Shen, Pengfei Guo, Karisa C Schreck, David Kamson, Lindsay Blair, Hye-Young Heo, Xu Li and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Qianqi HuangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jingpu WuDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Nhat LeDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yiqing ShenDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Pengfei GuoDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Karisa C SchreckDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
David KamsonDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Lindsay BlairDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Hye-Young HeoDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Xu LiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Wenbo LiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Haris L SairDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Malone Center for Engineering in Healthcare, The Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jaishri O BlakeleyDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
John LaterraDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Matthias HoldhoffDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Stuart A GrossmanDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Debraj MukherjeeDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Chetan BettegowdaDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Peter van ZijlDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Jinyuan ZhouDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Shanshan JiangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: sjiang21@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USKennedy Krieger Institute · US

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Quantitative CEST MRI for GBM Early Response Prediction and Biopsy GuidanceR37CA248077 · NCI · JOHNS HOPKINS UNIVERSITY · PI Shanshan Jiang · 2021 to 2026
$2.2M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
Amide Proton Transfer (APT) MRI of Brain Tumors at 3TR01CA228188 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2019 to 2022
$1.6M
NCI NIH HHS R01 CA228188NCI NIH HHS R37 CA248077NICHD NIH HHS P50 HD103538NIH HHS S10 OD021648
6 · The paper itself

Abstract

New or enlarged lesions in malignant gliomas after surgery and chemoradiation can be associated with tumor recurrence or treatment effect. Due to similar radiographic characteristics, conventional-and even some advanced MRI techniques-are limited in distinguishing these two pathologies. Amide proton transfer-weighted (APTw) MRI, a protein-based molecular imaging technique that does not require the administration of any exogenous contrast agent, was recently introduced into the clinical setting. In this study, we evaluated and compared the diagnostic performances of APTw MRI with several non-contrast-enhanced MRI sequences, such as diffusion-weighted imaging, susceptibility-weighted imaging, and pseudo-continuous arterial spin labeling. Thirty-nine scans from 28 glioma patients were obtained on a 3 T MRI scanner. A histogram analysis approach was employed to extract parameters from each tumor area. Statistically significant parameters (P < 0.05) were selected to train multivariate logistic regression models to evaluate the performance of MRI sequences. Multiple histogram parameters, particularly from APTw and pseudo-continuous arterial spin labeling images, demonstrated significant differences between treatment effect and recurrent tumor. The regression model trained on the combination of all significant histogram parameters achieved the best result (area under the curve = 0.89). We found that APTw images added value to other advanced MR images for the differentiation of treatment effect and tumor recurrence.

Indexed as

Brain NeoplasmsGliomaAmidesHumansMagnetic Resonance ImagingNeoplasm Recurrence, LocalProtonsAmidesProtonsAmide proton transfer-weighted imagingArterial spin labeling imagingGlioblastomaMagnetic resonance imagingTreatment effect

Identifiers

PMID37321378
PMCPMC10528251
OpenAlexW4380742056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.