ArticleDiabetes research and clinical practice2023
Diabetic foot disease and the risk of major clinical outcomes.
Article in Diabetes research and clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- A Systematic Review Examining the Association of Falls With Diabetes-Related Foot Ulcers.Journal of foot and ankle research · 2025Pooled it
- Diabetes-Related Foot Disease as the Principal Reason for Hospital Admission: 5 Years of Data From a Major Tertiary Hospital in Aotearoa New Zealand.Journal of foot and ankle research · 2026Article
- Multifunctional Hydrogels for Diabetic Wound Healing: Design Strategies and Microenvironmental Remodeling Mechanisms.Gels (Basel, Switzerland) · 2026Review
- Humanistic Care Needs of Hospitalised Patients With Diabetic Foot Ulcers: A Qualitative Descriptive Study From the Nurse-Patient Perspective.International wound journal · 2026Article
- Incidence and causes of major amputation in patients with diabetic foot ulcers: data from a retrospective study.Acta diabetologica · 2026Observational
- Explainable machine learning for differential diagnosis of diabetic foot infection and osteomyelitis: a two-center study and clinically applicable web calculator using routine blood biomarkers.BMC medical informatics and decision making · 2025Article
- Correlation between key indicators of continuous glucose monitoring and the risk of diabetic foot.World journal of diabetes · 2025Article
- The role of carbon dioxide angiography in reducing contrast-induced nephropathy in diabetic foot patients undergoing endovascular treatment.Turkish journal of medical sciences · 2025Article
- Screening and monitoring of diabetic polyneuropathy in clinical practice: present and future with connected devices.Frontiers in neurology · 2025Article
- Association of the neutrophil-to-lymphocyte ratio with sudden cardiac death in the patients with diabetic foot ulcer.Frontiers in endocrinology · 2025Article
- Survival Prediction in Diabetic Foot Ulcers: A Machine Learning Approach.Journal of clinical medicine · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsData on the long-term consequences of diabetic foot disease (DFD) are scarce. We examined the association between DFD and major clinical outcomes in patients with diabetes in the general population.
methodsWe conducted a prospective cohort analysis of 1,428 participants with diabetes in the Atherosclerosis Risk in Communities Study. DFD and four clinical outcomes (nontraumatic lower-extremity amputation, cardiovascular disease, major fall, and death) were captured through 2018 using administrative data. We used Cox regression models to evaluate the association between incident DFD (modeled as a time-varying exposure) and the subsequent risk of clinical outcomes.
resultsDuring over two decades of follow-up (1996-1998 to 2018), the cumulative incidence of DFD was 33.3%. Risk factors for DFD included older age, poor glycemic control, long diabetes duration, and prevalent vascular disease (chronic kidney disease, retinopathy, cardiovascular disease). Following incident DFD, the five-year cumulative incidence of major clinical outcomes was 38.9% for mortality, 25.2% for cardiovascular disease, 14.5% for nontraumatic lower-extremity amputation, and 13.2% for major fall. DFD remained associated with all four clinical outcomes after multivariable adjustment, with hazard ratios ranging from 1.5 (cardiovascular disease) to 34.7 (lower-extremity amputation).
conclusionsDFD is common and confers substantial risk for major morbidity and mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.