Evidence map›Paper›PMID 37321171›Full record

ReviewCell host & microbe2023

The coronavirus recombination pathway.

Heather L Wells, Cassandra M Bonavita, Isamara Navarrete-Macias, Blake Vilchez, Angela L Rasmussen, Simon J Anthony

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

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  14. Molecular and Clinical Study of Bovine Coronavirus andVeterinary medicine international · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heather L WellsDepartment of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY, USA; Department of Pathology, Microbiology, and Immunology, University of California Davis School of Veterinary Medicine, Davis, CA, USA. Electronic address: hlwells@ucdavis.edu.
Cassandra M BonavitaDepartment of Pathology, Microbiology, and Immunology, University of California Davis School of Veterinary Medicine, Davis, CA, USA.
Isamara Navarrete-MaciasDepartment of Pathology, Microbiology, and Immunology, University of California Davis School of Veterinary Medicine, Davis, CA, USA.
Blake VilchezDepartment of Pathology, Microbiology, and Immunology, University of California Davis School of Veterinary Medicine, Davis, CA, USA.
Angela L RasmussenVaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada.
Simon J AnthonyDepartment of Pathology, Microbiology, and Immunology, University of California Davis School of Veterinary Medicine, Davis, CA, USA. Electronic address: sjanthony@ucdavis.edu.

Funding

Genetic and ecological determinants of coronavirus recombinationR01AI149693 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ANTHONY, SIMON J · 2020 to 2023
$2.0M
NIAID NIH HHS R01 AI149693
6 · The paper itself

Abstract

Recombination is thought to be a mechanism that facilitates cross-species transmission in coronaviruses, thus acting as a driver of coronavirus spillover and emergence. Despite its significance, the mechanism of recombination is poorly understood, limiting our potential to estimate the risk of novel recombinant coronaviruses emerging in the future. As a tool for understanding recombination, here, we outline a framework of the recombination pathway for coronaviruses. We review existing literature on coronavirus recombination, including comparisons of naturally observed recombinant genomes as well as in vitro experiments, and place the findings into the recombination pathway framework. We highlight gaps in our understanding of coronavirus recombination illustrated by the framework and outline how further experimental research is critical for disentangling the molecular mechanism of recombination from external environmental pressures. Finally, we describe how an increased understanding of the mechanism of recombination can inform pandemic predictive intelligence, with a retrospective emphasis on SARS-CoV-2.

Indexed as

COVID-19SARS-CoV-2HumansPhylogenyRecombination, GeneticRetrospective Studiesbarrierscoronaviruscross-species transmissionevolutionpathwayrecombinationspillover

Identifiers

PMID37321171
PMCPMC10265781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.