Evidence map›Paper›PMID 37319406›Full record

ReviewAmerican journal of audiology2023

Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits.

Kristen Janky, Peter S Steyger

Open access · greenAbstract readReview
In one paragraph

Review in American journal of audiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kristen JankyDepartment of Audiology, Boys Town National Research Hospital, Omaha, NE.ORCID 0000-0001-5955-7506
Peter S SteygerBellucci Translational Hearing Center, Creighton University, Omaha, NE.ORCID 0000-0002-6103-5237
Boys Town National Research Hospital · USCreighton University · US

Funding

Understanding the progression of hearing loss in an endolymphatic hydrops modelP20GM139762 · NIGMS · CREIGHTON UNIVERSITY · PI Hui Hong · 2021 to 2026
$16.1M
Clinical factors in aminoglycoside-induced ototoxicityR01DC016680 · NIDCD · CREIGHTON UNIVERSITY · PI STEYGER, PETER STEPHEN · 2019 to 2023
$3.3M
OUTCOMES IN PEDIATRIC VESTIBULAR LOSSR03DC015318 · NIDCD · FATHER FLANAGAN'S BOYS' HOME · PI JANKY, KRISTEN L. · 2016 to 2018
$450k
Auditory Processing by Neural Circuits in the Inferior ColliculusR56DC016880 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERTS, MICHAEL THOMAS · 2018 to 2018
$312k
NIDCD NIH HHS R01 DC016680NIDCD NIH HHS R03 DC015318NIDCD NIH HHS R56 DC016880NIGMS NIH HHS P20 GM139762
6 · The paper itself

Abstract

purposeAcquired vestibulotoxicity from hospital-prescribed medications such as aminoglycoside antibiotics affects as many as 40,000 people each year in North America. However, there are no current federally approved drugs to prevent or treat the debilitating and permanent loss of vestibular function caused by bactericidal aminoglycoside antibiotics. This review will cover our current understanding of the impact of, and mechanisms underlying, aminoglycoside-induced vestibulotoxicity and highlight the gaps in our knowledge that remain.

conclusionsAminoglycoside-induced vestibular deficits have long-term impacts on patients across the lifespan. Additionally, the prevalence of aminoglycoside-induced vestibulotoxicity appears to be greater than cochleotoxicity. Thus, monitoring for vestibulotoxicity should be independent of auditory monitoring and encompass patients of all ages from young children to older adults before, during, and after aminoglycoside therapy.

Indexed as

AminoglycosidesVestibule, LabyrinthAgedAnti-Bacterial AgentsChildChild, PreschoolHumansAminoglycosidesAnti-Bacterial Agents

Identifiers

PMID37319406
PMCPMC10721243
OpenAlexW4380740650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.