Evidence map›Paper›PMID 37319294›Full record

ArticlePloS one2023

Objective perimetry identifies regional functional progression and recovery in mild Diabetic Macular Oedema.

Faran Sabeti, Bhim B Rai, Josh P van Kleef, Emilie M F Rohan, Corinne F Carle, Richard C Barry, Rohan W Essex, Christopher J Nolan, Ted Maddess

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Faran SabetiThe John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.ORCID 0000-0001-9187-7569
Bhim B RaiThe John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.ORCID 0000-0003-0748-4581
Josh P van KleefThe John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Emilie M F RohanThe John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Corinne F CarleThe John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Richard C BarryThe Canberra Hospital, ACT Health, Garran, Canberra, ACT, Australia.
Rohan W EssexThe Canberra Hospital, ACT Health, Garran, Canberra, ACT, Australia.
Christopher J NolanThe Canberra Hospital, ACT Health, Garran, Canberra, ACT, Australia.
Ted MaddessThe John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Australian National University · AUCanberra Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRetinal function beyond foveal vision is not routinely examined in the clinical screening and management of diabetic retinopathy although growing evidence suggests it may precede structural changes. In this study we compare optical coherence tomography (OCT) based macular structure with function measured objectively with the ObjectiveFIELD Analyzer (OFA), and with Matrix perimetry. We did that longitudinally in Type 2 diabetes (T2D) patients with mild Diabetic Macular Oedema (DMO) with good vision and a similar number of T2D patients without DMO, to evaluate changes in retinal function more peripherally over the natural course of retinopathy.

methodsBoth eyes of 16 T2D patients (65.0 ± 10.1, 10 females), 10 with baseline DMO, were followed for up longitudinally for 27 months providing 94 data sets. Vasculopathy was assessed by fundus photography. Retinopathy was graded using to Early Treatment of Diabetic Retinopathy Study (ETDRS) guidelines. Posterior-pole OCT quantified a 64-region/eye thickness grid. Retinal function was measured with 10-2 Matrix perimetry, and the FDA-cleared OFA. Two multifocal pupillographic objective perimetry (mfPOP) variants presented 44 stimuli/eye within either the central 30° or 60° of the visual field, providing sensitivities and delays for each test-region. OCT, Matrix and 30° OFA data were mapped to a common 44 region/eye grid allowing change over time to be compared at the same retinal regions.

resultsIn eyes that presented with DMO at baseline, mean retinal thickness reduced from 237 ± 25 μm to 234.2 ± 26.7 μm, while the initially non-DMO eyes significantly increased their mean thickness from 250.7 ± 24.4 μm to 255.7 ± 20.6 μm (both p<0.05). Eyes that reduced in retinal thickness over time recovered to more normal OFA sensitivities and delays (all p<0.021). Matrix perimetry quantified fewer regions that changed significantly over the 27 months, mostly presenting in the central 8 degrees.

conclusionsChanges in retinal function measured by OFA possibly offer greater power to monitor DMO over time than Matrix perimetry data.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathyMacular EdemaFemaleHumansRetinaTomography, Optical CoherenceVisual Field Tests

Identifiers

PMID37319294
PMCPMC10270604
OpenAlexW4380742343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.