ArticleScience (New York, N.Y.)2023
Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Transcriptomic meta-analysis identifies dysregulated pathways and potential therapeutic targets in Vestibular Schwannoma.PloS one · 2026Pooled it
- Platelet-derived serotonin epigenetically programs macrophage alternative activation to orchestrate type 2 airway inflammation.Cellular & molecular immunology · 2026Article
- Transglutaminase 2 Deletion Enhances Astrocyte-to-Neuron Metabolic Support and Attenuates Subacute Pathology Following Repetitive Mild Traumatic Brain Injury.bioRxiv : the preprint server for biology · 2026Article
- Delayed astrocyte development impairs Sema6a-Plxna2/4-mediated astrocyte-neuron crosstalk and causes depressive-like behavior.Nature communications · 2026Article
- Crosstalk of noradrenergic CaCell communication and signaling : CCS · 2026Article
- SLC22A3 regulates ferroptosis in the mesenchymal subtype of triple-negative breast cancer by modulating histone H3K4 serotonylation.Cell death & disease · 2026Article
- Epigenetic Regulation of Modulatory Neurotransmitter System Integrity in the Aging Brain: A Scoping Review Across the Lifespan.Life (Basel, Switzerland) · 2026Review
- Article
- Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes.Cellular & molecular biology letters · 2026Review
- SLC22A3 deficiency leads to cognitive impairment through the cardio-neuroinflammatory axis mediated HA/H1R/NLRP3 pathway in heart failure mice.Redox biology · 2026Article
- Serotonergic modulation of excitatory synapse development and plasticity.Molecules and cells · 2026Review
- Cellular and molecular mechanisms of astrocyte plasticity in learning and memory.Trends in neurosciences · 2026Review
- Compensatory Serotonin Synthesis and Histone H3 Serotonylation in Preimplantation Embryos Exposed to Maternal Fluoxetine or Monoamine Oxidase Blockade.Journal of developmental biology · 2026Article
- Quinone reductase 2bioRxiv : the preprint server for biology · 2026Article
- Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function.Nature neuroscience · 2026Article
- Reimagining biogenic amine signaling in the brain and beyond.Trends in neurosciences · 2026Review
- Neurobiology of resilience to early life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- PMAT enhances sexual dimorphism of fear behaviors and facilitates female mice's generalized contextual fear extinction.Frontiers in neuroscience · 2026Article
- Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Debosmita SardarCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8158-2185
Yi-Ting Cheng *Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8288-0707
Junsung Woo *Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Dong-Joo ChoiCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3222-7130
Zhung-Fu LeeCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6500-3179
Wookbong KwonCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-0655-6531
Hsiao-Chi ChenCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-7505-6119
Brittney LozziCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-6876-8479
Alexis CervantesCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Kavitha RajendranCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0002-4420-4577
Teng-Wei HuangCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8604-1262
Antrix JainMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2815-3645
Benjamin R ArenkielProgram in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9047-2420
Ian MazeNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-1490-7781
Benjamin DeneenCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6335-1081
Baylor College of Medicine · USAllen Institute for Brain Science · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MTranscriptional regulation of gliogenesis in the CNSR01NS071153 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2010 to 2022
$5.0MMAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONSR01NS078294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R · 2012 to 2023
$3.6MDefining Roles for Astrocyte Subpopulations in the Aging BrainR01AG071687 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2021 to 2025
$2.0MTHERMO SCIENTIFIC Q EXACTIVE HF-X HYBRID QUADRUPOLE-ORBITRAP MASS SPECTROMETERS10OD026804 · OD · BAYLOR COLLEGE OF MEDICINE · PI MALOVANNAYA, ANNA · 2019 to 2019
$717kAstrocyte transcriptional responses to neuronal activity in the olfactory bulbK99DC019668 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI SARDAR, DEBOSMITA · 2022 to 2023
$198kNCI NIH HHS P30 CA125123NHLBI NIH HHS T32 HL092332NIA NIH HHS R01 AG071687NICHD NIH HHS P50 HD103555NIDCD NIH HHS K99 DC019668NIH HHS S10 OD026804NINDS NIH HHS R01 NS071153NINDS NIH HHS R01 NS078294
Abstract
Neuronal activity drives alterations in gene expression within neurons, yet how it directs transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is unknown. We found that neuronal activity induces widespread transcriptional up-regulation and down-regulation in astrocytes, highlighted by the identification of
Indexed as
AstrocytesHistonesOlfactory BulbOlfactory PerceptionOrganic Cation Transport ProteinsSerotoninSynaptic TransmissionAnimalsEpigenesis, Geneticgamma-Aminobutyric AcidMiceOrganic Cation Transporter 3gamma-Aminobutyric AcidHistonesOrganic Cation Transporter 3Organic Cation Transport ProteinsSerotonin
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.