ArticleScience (New York, N.Y.)2023
Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution.
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Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75citing papers in PubMed
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Who cites it
75 citing papers in PubMed.
- Cell-type-specific circadian and light-responsive transcriptional dynamics in adultProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural decomposition enables multi-omics dissection of common and organ-specific aging.Science China. Life sciences · 2026Article
- Article
- Hippo signaling regulates cuticle pigmentation and dopamine metabolism in Drosophila.PLoS genetics · 2026Article
- Enteric viral infections promote systemic accelerated aging inScience advances · 2026Article
- Longitudinal lineage tracing reveals early clonal attrition during Drosophila midgut aging.PLoS biology · 2026Article
- The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration.Aging cell · 2026Review
- Intrinsic regulation of intestinal stem cell fate and homeostasis by Tet.bioRxiv : the preprint server for biology · 2026Article
- Chlorophyll Supplementation Delays Aging inNutrients · 2026Article
- Article
- An snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging.Scientific reports · 2026Article
- Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.Cell genomics · 2026Article
- A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity.Cell genomics · 2026Article
- Sex-specific differences in mediobasal hypothalamus in response to nutritional states.Nature communications · 2026Article
- Single-nucleus transcriptome profiling of wild boar and domestic pig intestines reveals the spatiotemporal dynamics of immunity and nutrient absorption.Science China. Life sciences · 2026Article
- Glycerol 3-phosphate acyltransferase exacerbates α-synuclein-induced toxicity by increasing lipid peroxidation.Nature communications · 2026Article
- Organ-Specific Regulation of Systemic Aging: Focus on the Brain, Skeletal Muscle, and Gut.Cells · 2026Review
- Article
- Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration.Nucleic acids research · 2026Article
- Tissue-specific aging-a new paradigm based on transcriptional insights from select model systems and humans.Frontiers in genetics · 2026Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Tzu-Chiao Lu *Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9942-2307
Maria Brbić *School of Computer and Communication Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland.ORCID 0000-0002-1120-1778
Ye-Jin ParkHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8066-4194
Tyler JacksonHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2988-4340
Jiaye ChenHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9654-1968
Sai Saroja KolluruDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3748-8519
Yanyan QiHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Nadja Sandra KathederRegenerative Medicine, Genentech, Inc., South San Francisco, CA 94080, USA.ORCID 0000-0003-0460-0938
Xiaoyu Tracy CaiRegenerative Medicine, Genentech, Inc., South San Francisco, CA 94080, USA.
Seungjae LeeDevelopmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.ORCID 0000-0001-5626-9656
Yen-Chung ChenDepartment of Biology, New York University, New York, NY 10013, USA.ORCID 0000-0002-8529-1251
Niccole AuldHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-5711-9430
Chung-Yi LiangHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-3352-775X
Sophia H DingHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0006-7546-5197
Doug WelschHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3873-9586
Samuel D'SouzaChan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Angela Oliveira PiscoChan Zuckerberg Biohub, San Francisco, CA 94158, USA.ORCID 0000-0003-0142-2355
Robert C JonesDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-7235-9854
Jure LeskovecDepartment of Computer Science, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-5411-923X
Eric C LaiDevelopmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.ORCID 0000-0002-8432-5851
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-5992-5989
Liqun LuoHoward Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-5467-9264
Heinrich JasperRegenerative Medicine, Genentech, Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-6014-4343
Stephen R QuakeDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-1613-0809
Hongjie LiHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7332-7122
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MSelective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8MAssembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1MMechanism and regulation of Hu family RNA binding proteins during neural alternative polyadenylationR01NS083833 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2014 to 2023
$5.4MTraining Program in Cell and Molecular BiologyT32GM136560 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Rachel Nicole Arey, WEEI-CHIN LIN · 2020 to 2026
$3.9MCharacterizing age-related decline of neural circuits by single-cell profilingR00AG062746 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LI, HONGJIE · 2021 to 2023
$996kNCI NIH HHS P30 CA008748NIA NIH HHS R00 AG062746NIDCD NIH HHS R01 DC005982NIGMS NIH HHS R01 GM083300NIGMS NIH HHS T32 GM136560NINDS NIH HHS R01 NS083833
Abstract
Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging
Indexed as
AgingCellular SenescenceDrosophila melanogasterAnimalsAtlases as TopicGene Expression ProfilingTranscriptome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.