Evidence map›Paper›PMID 37318993›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage.

Samuel D Walton, John Henry Dasinger, Emily C Burns, Mary Cherian-Shaw, Justine M Abais-Battad, David L Mattson

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Samuel D WaltonDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0002-8460-2214
John Henry DasingerDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Emily C BurnsDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Mary Cherian-ShawDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Justine M Abais-BattadDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0001-5252-0903
David L MattsonDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Augusta University · US

Funding

Gut Metabolites, T cells, and Salt-Sensitive HypertensionR01HL166458 · NHLBI · AUGUSTA UNIVERSITY · PI David L. Mattson, Aaron James Polichnowski · 2023 to 2026
$2.4M
CD14 and Salt-Sensitive HypertensionR01HL161231 · NHLBI · AUGUSTA UNIVERSITY · PI MATTSON, DAVID L. · 2022 to 2025
$2.0M
NHLBI NIH HHS R01 HL161231NHLBI NIH HHS R01 HL166458
6 · The paper itself

Abstract

Infiltrating T cells in the kidney amplify salt-sensitive (SS) hypertension and renal damage, but the mechanisms are not known. Genetic deletion of T cells (SS

Indexed as

HypertensionSodium ChlorideAlbuminuriaAnimalsKidneyNADPH Oxidase 2NADPH OxidasesRatsRats, Inbred DahlReactive Oxygen SpeciesSodium Chloride, DietaryT-LymphocytesNADPH Oxidase 2NADPH OxidasesReactive Oxygen SpeciesSodium ChlorideSodium Chloride, DietaryhypertensionNADPH oxidasep67phoxrenal damageT cells

Identifiers

PMID37318993
PMCPMC10396224
OpenAlexW4380786403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.