ArticleCardiology and therapy2023
Correlation of RETINAL Artery Diameter with Coronary Artery Disease: The RETINA CAD Pilot Study-Are the Eyes the Windows to the Heart?
Article in Cardiology and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04233619 (Correlation of Microvascular Ophthalmic Disease With Macrovascular Coronary Artery Disease in Trinidad), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation of Microvascular Ophthalmic Disease With Macrovascular Coronary Artery Disease in Trinidad: The EYE-MI TNT Study
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- The value of retinal microvascular features in predicting risk stratification and long-term prognosis of patients with acute coronary syndrome.BMC ophthalmology · 2026Article
- Prediction of coronary artery disease using retinal optical coherence tomography angiography imaging and electronic health records: a multimodal machine learning approach.BMC cardiovascular disorders · 2026Article
- Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease.Investigative ophthalmology & visual science · 2025Article
- Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article.Eye (London, England) · 2025Review
- Coronary artery and retinal vascularization by optical coherence tomography angiography: are eyes the window to the heart?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Artificial intelligence in managing retinal disease-current concepts and relevant aspects for health care providers.Wiener medizinische Wochenschrift (1946) · 2025Review
- Retinal Microvascular Profile of Patients with Coronary Artery Disease.Medicina (Kaunas, Lithuania) · 2025Article
- Retinal Microangiopathy as a Marker of Coronary Atherosclerotic Heart Disease.International journal of general medicine · 2025Review
- Predicting the Degree of Coronary Artery Stenosis Through Retinal Vascular Characteristics and Minimal Clinical Information.International journal of general medicine · 2025Article
- Severity Stratification of Coronary Artery Disease Using Novel Inner Ellipse-Based Foveal Avascular Zone Biomarkers.Investigative ophthalmology & visual science · 2024Article
- Association between retinal AV ratio and coronary artery disease severity in acute coronary syndrome and chronic coronary syndrome patients: A prospective study.Indian heart journalArticle
- Optical coherence tomography angiography in cardiovascular disease.Progress in cardiovascular diseasesReview
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to determine whether there was any correlation between coronary artery disease (CAD) and retinal artery diameter at an academic tertiary medical center in Trinidad and Tobago.
methodsThis prospective study evaluated patients (n = 77) with recent invasive coronary angiography (CAG) and the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score who subsequently underwent optical coherence tomography-angiography (OCT-A) at the Eric Williams Medical Sciences Complex (EWMSC) from January 2021 to March 2021. Routine medical history and cardiovascular medications were also recorded. Spearman's rank correlation coefficient and Mann-Whitney U-tests were used to compare correlations and medians between groups.
resultsThe average patient age was 57.8 years old, with the majority being male [n = 55 (71.4%)] and of South Asian ethnicity [n = 53 (68.8%)]. Retinal artery diameter was negatively correlated with the SYNTAX score (-0.332 for the right eye, p = 0.003 and -0.237 for the left eye, p = 0.038). A statistically significant relationship was also demonstrated in females and diabetic patients. There were no serious adverse events (SAEs).
conclusionA significantly negative correlation was observed between retinal artery diameter and SYNTAX score. This study alludes to the practical use of optical coherence tomography-angiography (OCT-A) as a noninvasive diagnostic modality for patients with cardiovascular disease (CVD). Further large-scale, multicentric studies are required to confirm these exploratory findings. TRIAL REGISTRATION NUMBER: NCT04233619.
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