Evidence map›Paper›PMID 37318672›Full record

ReviewGlycoconjugate journal2023

Mucin glycans and their degradation by gut microbiota.

Masanori Yamaguchi, Kenji Yamamoto

Abstract readReview
PubMed Publisher
In one paragraph

Review in Glycoconjugate journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  6. ACS omega · 2025
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  7. Review
  8. Article
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  10. Review
  11. Review
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  16. Colonization byFrontiers in immunology · 2025
    Article
  17. Article
  18. Article
  19. Revealing Glycosylation Patterns inJournal of agricultural and food chemistry · 2024
    Article
  20. Prebiotic effect of galacto-Applied and environmental microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Masanori YamaguchiDepartment of Organic Bio Chemistry, Faculty of Education, Wakayama University, 930, Sakaedani, Wakayama, 640-8510, Japan. masayama@wakayama-u.ac.jp.
Kenji YamamotoCenter for Innovative and Joint Research, Wakayama University, 930, Sakaedani, Wakayama, 640-8510, Japan.
Wakayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human intestinal tract is inhabited by a tremendous number of microorganisms, which are collectively termed "the gut microbiota". The intestinal epithelium is covered with a dense layer of mucus that prevents penetration of the gut microbiota into underlying tissues of the host. Recent studies have shown that the maturation and function of the mucus layer are strongly influenced by the gut microbiota, and alteration in the structure and function of the gut microbiota is implicated in several diseases. Because the intestinal mucus layer is at a crucial interface between microbes and their host, its breakdown leads to gut bacterial invasion that can eventually cause inflammation and infection. The mucus is composed of mucin, which is rich in glycans, and the various structures of the complex carbohydrates of mucins can select for distinct mucosa-associated bacteria that are able to bind mucin glycans, and sometimes degrade them as a nutrient source. Mucin glycans are diverse molecules, and thus mucin glycan degradation is a complex process that requires a broad range of glycan-degrading enzymes. Because of the increased recognition of the role of mucus-associated microbes in human health, how commensal bacteria degrade and use host mucin glycans has become of increased interest. This review provides an overview of the relationships between the mucin glycan of the host and gut commensal bacteria, with a focus on mucin degradation.

Indexed as

Gastrointestinal MicrobiomeMucinsCarbohydratesHumansIntestinal MucosaPolysaccharidesCarbohydratesMucinsPolysaccharidesCarbohydrate-active enzymesGlycosaminoglycansInflammatory bowel diseasesMicrobiotaMucinO-Glycan

Identifiers

PMID37318672
OpenAlexW4380608045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.