Evidence map›Paper›PMID 37318434›Full record

ArticleAnnals of emergency medicine2023

Impact of Universal Screening and Automated Clinical Decision Support for the Treatment of Opioid Use Disorder in Emergency Departments: A Difference-in-Differences Analysis.

Margaret Lowenstein, Jeanmarie Perrone, Rachel McFadden, Ruiying Aria Xiong, Zachary F Meisel, Nicole O'Donnell, Dina Abdel-Rahman, Jeffrey Moon, Nandita Mitra, Mucio Kit Delgado

Open access · hybridAbstract read
In one paragraph

Article in Annals of emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Lock and Protect, Reducing Access to Adolescent Means of Suicide: A Pilot Feasibility Study.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026
    Article
  3. Linkage to Outpatient Methadone Treatment From the Emergency Department and Hospital.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025
    Article
  4. Article
  5. Racial, ethnic, and sex disparities in buprenorphine treatment from emergency departments by discharge diagnosis.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Trends in the Prescribing of Buprenorphine for Opioid Use Disorder, 2019-2023.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Margaret LowensteinDivision of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Center for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, PA. Electronic address: margaw@pennmedicine.upenn.edu.
Jeanmarie PerroneDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Center for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, PA.
Rachel McFaddenDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Center for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, PA.
Ruiying Aria XiongDivision of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Penn Medicine Nudge Unit, University of Pennsylvania Health System, Philadelphia, PA.
Zachary F MeiselDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Nicole O'DonnellDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Center for Addiction Medicine and Policy, University of Pennsylvania, Philadelphia, PA.
Dina Abdel-RahmanDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Penn Medicine Nudge Unit, University of Pennsylvania Health System, Philadelphia, PA.
Jeffrey MoonDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Nandita MitraDepartment of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Mucio Kit DelgadoDepartment of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Penn Medicine Nudge Unit, University of Pennsylvania Health System, Philadelphia, PA.
University of Pennsylvania · USUniversity of Pennsylvania Health System · US

Funding

CE19-001, The Penn Injury Science CenterR49CE003083 · CE · UNIVERSITY OF PENNSYLVANIA · PI MEISEL, ZACHARY FRANKLIN · 2018 to 2023
$4.4M
Improving transitions of care for hospitalized patients with opioid use disorderK23DA055087 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Margaret Lowenstein · 2022 to 2026
$959k
NCIPC CDC HHS R49 CE003083NIDA NIH HHS K23 DA055087
6 · The paper itself

Abstract

STUDY

objectiveEmergency department (ED)-initiated buprenorphine improves outcomes in patients with opioid use disorder; however, adoption varies widely. To reduce variability, we implemented a nurse-driven triage screening question in the electronic health record to identify patients with opioid use disorder, followed by targeted electronic health record prompts to measure withdrawal and guide next steps in management, including initiation of treatment. Our objective was to assess the impact of screening implementation in 3 urban, academic EDs.

methodsWe conducted a quasiexperimental study of opioid use disorder-related ED visits using electronic health record data from January 2020 to June 2022. The triage protocol was implemented in 3 EDs between March and July 2021, and 2 other EDs in the health system served as controls. We evaluated changes in treatment measures over time and used a difference-in-differences analysis to compare outcomes in the 3 intervention EDs with those in the 2 controls.

resultsThere were 2,462 visits in the intervention hospitals (1,258 in the preperiod and 1,204 in the postperiod) and 731 in the control hospitals (459 in the preperiod and 272 in the postperiod). Patient characteristics within the intervention and control EDs were similar across the time periods. Compared with the control hospitals, the triage protocol was associated with a 17% greater increase in withdrawal assessment, using the Clinical Opioid Withdrawal Scale (COWS) (95% CI 7 to 27). Buprenorphine prescriptions at discharge also increased by 5% (95% CI 0% to 10%), and naloxone prescriptions increased by 12% points (95% CI 1% to 22%) in the intervention EDs relative to controls.

conclusionAn ED triage screening and treatment protocol led to increased assessment and treatment of opioid use disorder. Protocols designed to make screening and treatment the default practice have promise in increasing the implementation of evidence-based treatment ED opioid use disorder care.

Indexed as

BuprenorphineDecision Support Systems, ClinicalOpioid-Related DisordersEmergency Service, HospitalHumansNarcotic AntagonistsBuprenorphineNarcotic Antagonists

Identifiers

PMID37318434
PMCPMC11019868
OpenAlexW4380729834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.