Evidence map›Paper›PMID 37318345›Full record

ArticleMicrobiology spectrum2023

A Machine Learning-Based Analytic Pipeline Applied to Clinical and Serum IgG Immunoproteome Data To Predict Chlamydia trachomatis Genital Tract Ascension and Incident Infection in Women.

Chuwen Liu, Neha Vivek Mokashi, Toni Darville, Xuejun Sun, Catherine M O'Connell, Katrin Hufnagel, Tim Waterboer, Xiaojing Zheng

Abstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Anti-International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chuwen LiuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Neha Vivek MokashiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Toni DarvilleDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Xuejun SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Catherine M O'ConnellDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8229-684X
Katrin HufnagelInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany.
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany.
Xiaojing ZhengDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-2248-933X

Funding

The UPMC Sexually Transmitted Infections Cooperative Research CenterU19AI084024 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIESENFELD, HAROLD C · 2009 to 2013
$12.9M
University of North Carolina - Chlamydia Vaccine Initiative (UNC-CVI)U19AI144181 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI · 2019 to 2023
$10.7M
Natural Immunity Against Chlamydia trachomatisR01AI119164 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI · 2016 to 2020
$3.6M
NIAID NIH HHS R01 AI119164NIAID NIH HHS U19 AI084024NIAID NIH HHS U19 AI144181
6 · The paper itself

Abstract

We developed a reusable and open-source machine learning (ML) pipeline that can provide an analytical framework for rigorous biomarker discovery. We implemented the ML pipeline to determine the predictive potential of clinical and immunoproteome antibody data for outcomes associated with Chlamydia trachomatis (

Indexed as

Chlamydia InfectionsChlamydia trachomatisBayes TheoremBiomarkersFemaleGenitaliaHumansImmunoglobulin GMachine LearningReproducibility of ResultsBiomarkersImmunoglobulin GascensionbiomarkerChlamydia genital tract infectionincident infectionmachine learningpipeline

Identifiers

PMID37318345
PMCPMC10434056

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.