Evidence map›Paper›PMID 37318106›Full record

ArticleSchizophrenia bulletin2024

Childhood Adversity and Emerging Psychotic Experiences: A Network Perspective.

Zhiling Qiao, Ginette Lafit, Aleksandra Lecei, Robin Achterhof, Olivia J Kirtley, Anu P Hiekkaranta, Noëmi Hagemann, Karlijn S F M Hermans, Bart Boets, Ulrich Reininghaus and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

Zhiling QiaoDepartment of Neurosciences, Research Group Psychiatry, Center for Clinical Psychiatry, KU Leuven, Leuven, Belgium.ORCID 0000-0003-0221-470X
Ginette LafitDepartment of Neurosciences, Research Group Psychiatry, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.
Aleksandra LeceiDepartment of Neurosciences, Research Group Psychiatry, Center for Clinical Psychiatry, KU Leuven, Leuven, Belgium.
Robin AchterhofDepartment of Neurosciences, Research Group Psychiatry, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.
Olivia J KirtleyDepartment of Neurosciences, Research Group Psychiatry, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.
Anu P HiekkarantaDepartment of Neurosciences, Research Group Psychiatry, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.
Noëmi HagemannDepartment of Neurosciences, Research Group Psychiatry, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.
Karlijn S F M HermansStrategy and Academic Affairs, Administration and Central Services, Leiden University, Leiden, The Netherlands.
Bart BoetsDepartment of Neurosciences, Research Group Psychiatry, Center for Developmental Psychiatry, KU Leuven, Leuven, Belgium.
Ulrich ReininghausDepartment of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany.
Inez Myin-GermeysDepartment of Neurosciences, Research Group Psychiatry, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.
Ruud van WinkelDepartment of Neurosciences, Research Group Psychiatry, Center for Clinical Psychiatry, KU Leuven, Leuven, Belgium.
KU Leuven · BEKing's College London · GBLeiden University · NL

Funding

China Scholarship Council 202009110102Excellence of Science EOS G0E8718N/HUMVISCATFunds Julie Renson, Queen Fabiola and King Baudoin FoundationFWO G0C7816NFWO PhD Fellowship 1104219NFWO Senior Clinical Fellowship 1803616NFWO Senior Postdoctoral Fellowship 1257821NGerman Research Foundation Heisenberg professorship 389624707Research Foundation Flanders G049219N
6 · The paper itself

Abstract

background and hypothesisChildhood adversity is associated with a myriad of psychiatric symptoms, including psychotic experiences (PEs), and with multiple psychological processes that may all mediate these associations. STUDY

designUsing a network approach, the present study examined the complex interactions between childhood adversity, PEs, other psychiatric symptoms, and multiple psychological mediators (ie, activity-related and social stress, negative affect, loneliness, threat anticipation, maladaptive cognitive emotion regulation, attachment insecurity) in a general population, adolescent sample (n = 865, age 12-20, 67% female). STUDY

resultsCentrality analyses revealed a pivotal role of depression, anxiety, negative affect, and loneliness within the network and a bridging role of threat anticipation between childhood adversity and maladaptive cognitive emotion regulation. By constructing shortest path networks, we found multiple existing paths between different categories of childhood adversity and PEs, with symptoms of general psychopathology (ie, anxiety, hostility, and somatization) as the main connective component. Sensitivity analyses confirmed the robustness and stability of the networks. Longitudinal analysis in a subsample with Wave 2 data (n = 161) further found that variables with higher centrality (ie, depression, negative affect, and loneliness) better predicted follow-up PEs.

conclusionsPathways linking childhood adversity to PEs are complex, with multifaceted psychological and symptom-symptom interactions. They underscore the transdiagnostic, heterotypic nature of mental ill-health in young people experiencing PEs, in agreement with current clinical recommendations.

Indexed as

Adverse Childhood ExperiencesMental DisordersPsychotic DisordersAdolescentAdultAnxietyAnxiety DisordersChildFemaleHumansMaleYoung Adultadolescentschildhood adversitynetwork analysispsychotic experiences

Identifiers

PMID37318106
PMCPMC10754171
OpenAlexW4380675269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.