Evidence map›Paper›PMID 37317920›Full record

ArticleCurrent pharmaceutical biotechnology2026

Identifying 2PHDO as a SOCE Inhibitor from Chinese Herbal Extracts.

Jindou Liu, Hao Deng, Yaxin Li, Yangchun Du, Liuqing Wang, Yuqing Wang, Jin Liu, Chao Xi, Ping Gao, Yandong Zhou and 4 more

Abstract read
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In one paragraph

Article in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jindou LiuBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Hao DengThe Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yaxin LiBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Yangchun DuBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Liuqing WangBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Yuqing WangBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Jin LiuBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Chao XiBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Ping GaoBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Yandong ZhouDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Han LingGuangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, China.
Donald L GillDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Chuanjian LuGuangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, China.
Youjun WangBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China.

Funding

Guangdong Province Science and Technology Planning Project 2020B1212030006Ministry of Science and Technology of China 2019YFA0802104National Natural Science Foundation of China 91954205
6 · The paper itself

Abstract

backgroundSTIM- and Orai-mediated store operated calcium entry (SOCE) is a ubiquitous Ca METHODOLOGY: In this study, we identified a novel SOCE inhibitor named 2PHDO from a small pool of Chinese herbal extracts used for treating psoriasis. It could block SOCE and SOCEmediated NFAT translocation in multiple types of cells with a half inhibitory concentration around 1 μM. At this concentration, 2PHDO was specific for SOCE. Mechanistically, 2PHDO didn't affect the activation of STIM1 or its physical coupling with Orai1. Rather, 2PHDO inhibited SOCE via its actions on Orai1.

results2PHDO may serve as a good template for developing new medicines aiming to treat SOCE related diseases.

conclusionOverall, we proved the feasibility of screening and identification of novel SOCE inhibitors from active monomers of Chinese herbal medicine.

Indexed as

Calcium SignalingDrugs, Chinese HerbalAnimalsCalciumHEK293 CellsHumansNeoplasm ProteinsNFATC Transcription FactorsORAI1 ProteinStromal Interaction Molecule 1CalciumDrugs, Chinese HerbalNeoplasm ProteinsNFATC Transcription FactorsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 12PHDOchinese herbal medicineinhibitorOrai1SOCESTIM1

Identifiers

PMID37317920

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.