Evidence map›Paper›PMID 37317905›Full record

ArticleCardiovascular & hematological agents in medicinal chemistry2024

Philadelphia Chromosome Positive Chronic Myelogenous Leukemia Blastic Crisis in a Patient with Unusual Primary Myelofibrosis Characteristics; A Case Report.

Elahe Razmara Lak, Sedigheh Sharifzadeh, Mani Ramzi, Maral Mokhtari, Reza Asadpouri, Elham Abedi, Gholamhossein Tamaddon

Abstract readCase Reports
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In one paragraph

Article in Cardiovascular & hematological agents in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Elahe Razmara LakDepartment of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Sedigheh SharifzadehDiagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Mani RamziHematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maral MokhtariDepartment of Pathology, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Reza AsadpouriDepartment of Medical Parasitology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Iran.
Elham AbediHematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Gholamhossein TamaddonDiagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMyeloproliferative neoplasms (MPNs) are divided into BCR-ABL positive Chronic myeloid leukemia (CML) and BCR-ABL negative MPNs including Polycythemia vera (PV), Essential Thrombocythemia (ET) and Primary myelofibrosis (PMF). Evaluation of the Philadelphia chromosome in MPNs is a diagnostic requirement for classic CML. CASE REPORT: In 2020, a 37-year-old woman with negative cytogenetic testing for Janus kinase2 (JAK2), Calreticulin (CALR), myeloproliferative leukemia virus oncogene (MPL), and positive for BCR-ABL1 mutation with reticular fibrosis in bone marrow was diagnosed as CML. Some years ago, the patient had been diagnosed with PMF with evidence of histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto disease (KFD). The BCR-ABL fusion gene was initially evaluated which was negative. Then, Cutaneous squamous cell carcinoma (cSCC) was confirmed by Dermatopathologist with palpable splenomegaly and high white blood cell (WBC) count with basophilia. Finally, BCR-ABL was detected positive by the fluorescence

conclusionThis case study highlighted the importance of some cytogenetic methods in the detection and classification of MPNs. It is recommended that physicians pay more attention to it and be aware of the planning treatment.

Indexed as

Blast CrisisFusion Proteins, bcr-ablLeukemia, Myelogenous, Chronic, BCR-ABL PositivePhiladelphia ChromosomePrimary MyelofibrosisAdultCarcinoma, Squamous CellFemaleHumansSkin NeoplasmsFusion Proteins, bcr-ablBCR-ABL positive chronic myeloid leukemiacutaneous squamous cell carcinomafluorescence in situ hybridization.histiocytic necrotizing lymphadenitismyeloproliferative neoplasmsprimary myelofibrosis

Identifiers

PMID37317905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.