Evidence map›Paper›PMID 37317861›Full record

Trial reportAnnals of surgery2023

Randomized Controlled Trial of Surgical Rib Fixation to Nonoperative Management in Severe Chest Wall Injury.

David E Meyer, John A Harvin, Laura Vincent, Kandice Motley, Michael W Wandling, Thaddeus J Puzio, Laura J Moore, Bryan A Cotton, Charles E Wade, Lillian S Kao

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Comparison of flail and multiple simple rib fracture patterns among patients included in rib fracture studies; A systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. From rib fixation to dynamic chest wall reconstruction: historical lessons for modern surgical stabilization of rib fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Review
  6. ARDS management in trauma patients.Intensive care medicine · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Two-center retrospective study comparing intramedullary and plate fixation for rib fractures on safety and cost-effectiveness.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
    Article
  14. Article
  15. Review
  16. Article
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  19. Review
  20. Comment on: "Randomized Controlled Trial of Surgical Rib Fixation to Nonoperative Management in Severe Chest Wall Injury".Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David E MeyerDepartment of Surgery; McGovern Medical School at UTHealth Houston, Houston, TX.ORCID 0000-0002-3816-0160
John A HarvinDepartment of Surgery; McGovern Medical School at UTHealth Houston, Houston, TX.
Laura VincentThe Center for Translational Injury Research, McGovern Medical School at UTHealth Houston, Houston, TX.
Kandice MotleyThe Center for Translational Injury Research, McGovern Medical School at UTHealth Houston, Houston, TX.
Michael W WandlingDepartment of Surgery; McGovern Medical School at UTHealth Houston, Houston, TX.
Thaddeus J PuzioDepartment of Surgery; McGovern Medical School at UTHealth Houston, Houston, TX.ORCID 0000-0003-4150-5956
Laura J MooreDepartment of Surgery; McGovern Medical School at UTHealth Houston, Houston, TX.ORCID 0000-0002-0736-1832
Bryan A CottonDepartment of Surgery; McGovern Medical School at UTHealth Houston, Houston, TX.
Charles E WadeThe Center for Translational Injury Research, McGovern Medical School at UTHealth Houston, Houston, TX.ORCID 0000-0003-0055-5885
Lillian S KaoDepartment of Surgery; McGovern Medical School at UTHealth Houston, Houston, TX.
The University of Texas Health Science Center at Houston · US

Funding

Institutional Career Development CoreKL2TR003168 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, CHARLES C · 2019 to 2023
$4.9M
NCATS NIH HHS KL2 TR003168
6 · The paper itself

Abstract

objectiveTo compare the effectiveness of surgical stabilization of rib fractures (SSRFs) to nonoperative management in severe chest wall injury.

backgroundSSRF has been shown to improve outcomes in patients with clinical flail chest and respiratory failure. However, the effect of SSRF outcomes in severe chest wall injuries without clinical flail chest is unknown.

methodsRandomized controlled trial comparing SSRF to nonoperative management in severe chest wall injury, defined as: (1) a radiographic flail segment without clinical flail or (2) ≥5 consecutive rib fractures or (3) any rib fracture with bicortical displacement. Randomization was stratified by the unit of admission as a proxy for injury severity. Primary outcome was hospital length of stay (LOS). Secondary outcomes included intensive care unit (ICU) LOS, ventilator days, opioid exposure, mortality, and incidences of pneumonia and tracheostomy. Quality of life at 1, 3, and 6 months was measured using the EQ-5D-5L survey.

resultsEighty-four patients were randomized in an intention-to-treat analysis (usual care = 42, SSRF = 42). Baseline characteristics were similar between groups. The numbers of total fractures, displaced fractures, and segmental fractures per patient were also similar, as were the incidences of displaced fractures and radiographic flail segments. Hospital LOS was greater in the SSRF group. ICU LOS and ventilator days were similar. After adjusting for the stratification variable, hospital LOS remained greater in the SSRF group (RR: 1.48, 95% CI: 1.17-1.88). ICU LOS (RR: 1.65, 95% CI: 0.94-2.92) and ventilator days (RR: 1.49, 95% CI: 0.61--3.69) remained similar. Subgroup analysis showed that patients with displaced fractures were more likely to have LOS outcomes similar to their usual care counterparts. At 1 month, SSRF patients had greater impairment in mobility [3 (2-3) vs 2 (1-2), P = 0.012] and self-care [2 (1-2) vs 2 (2-3), P = 0.034] dimensions of the EQ-5D-5L.

conclusionsIn severe chest wall injury, even in the absence of clinical flail chest, the majority of patients still reported moderate to extreme pain and impairment of usual physical activity at one month. SSRF increased hospital LOS and did not provide any quality of life benefit for up to 6 months.

Indexed as

Flail ChestRib FracturesThoracic WallHumansLength of StayQuality of LifeRetrospective StudiesRibs

Identifiers

PMID37317861
PMCPMC10527348
OpenAlexW4380730676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.