ArticleMagnetic resonance in medicine2023
Validation of the presence of fast exchanging amine CEST effect at low saturation powers and its influence on the quantification of APT.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Effective Modeling of Continuous WaveMagnetic resonance in medicine · 2026Article
- Multimodal MRI Reveals Cerebral and Vascular Amyloid-Driven Myeloarchitectural Disorganization in a Mouse Model of Alzheimer's Disease.NMR in biomedicine · 2026Article
- Denoising Low-Power CEST Imaging Using a Deep Learning Approach With a Dual-Power Feature Preparation Strategy.Magnetic resonance in medicine · 2026Article
- Accelerating CEST MRI through complementary undersampling and multi-offset transformer reconstruction.Communications engineering · 2026Article
- Interpreting amide proton transfer-weighted imaging contrast between normal and tumor brain tissues using the asymmetry analysis method at 4.7 T.Magnetic resonance in medicine · 2026Article
- Molecular subgrouping of pediatric medulloblastoma by mismatch between molecular and structural MRI.Quantitative imaging in medicine and surgery · 2025Article
- Saturation transfer MR fingerprinting for magnetization transfer contrast and chemical exchange saturation transfer quantification.Magnetic resonance in medicine · 2025Article
- Toward quantitative CEST imaging of glutamate in the mouse brain using a multi-pool exchange model calibrated byMagnetic resonance in medicine · 2025Article
- Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z-spectroscopy (UFZ) MRI at 3T.Magnetic resonance in medicine · 2025Article
- Improving quantification accuracy of a nuclear Overhauser enhancement signal at -1.6 ppm at 4.7 T using a machine learning approach.Physics in medicine and biology · 2025Article
- Enhancing amide proton transfer imaging in ischemic stroke using a machine learning approach with partially synthetic data.NMR in biomedicine · 2025Article
- Improving standardization and accuracy of in vivo omega plot exchange parameter determination using rotating-frame model-based fitting of quasi-steady-state Z-spectra.Magnetic resonance in medicine · 2025Article
- Unraveling contributions to the Z-spectrum signal at 3.5 ppm of human brain tumors.Magnetic resonance in medicine · 2024Article
- Amide proton transfer MRI at 9.4 T for differentiating tissue acidosis in a rodent model of ischemic stroke.Magnetic resonance in medicine · 2024Article
- Whole-cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack-of-spirals gradient echo acquisition.Magnetic resonance in medicine · 2024Article
- A Denoising Convolutional Autoencoder for SNR Enhancement in Chemical Exchange Saturation Transfer imaging: (DCAE-CEST).bioRxiv : the preprint server for biology · 2024Article
- Machine learning-based amide proton transfer imaging using partially synthetic training data.Magnetic resonance in medicine · 2024Article
- Specific and rapid guanidinium CEST imaging using double saturation power and QUASS analysis in a rodent model of global ischemia.Magnetic resonance in medicine · 2024Article
- A rapid method for phosphocreatine-weighted imaging in muscle using double saturation power-chemical exchange saturation transfer.NMR in biomedicine · 2024Article
- CEST and nuclear Overhauser enhancement imaging with deep learning-extrapolated semisolid magnetization transfer reference: Scan-rescan reproducibility and reliability studies.Magnetic resonance in medicine · 2024Article
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Abstract
purposeAccurately quantifying the amide proton transfer (APT) effect and the underlying exchange parameters is crucial for its applications, but previous studies have reported conflicting results. In these quantifications, the CEST effect from the fast exchange amine was always ignored because it was considered weak with low saturation powers. This paper aims to evaluate the influence of the fast exchange amine CEST on the quantification of APT at low saturation powers.
methodsA quantification method with low and high saturation powers was used to distinguish APT from the fast exchange amine CEST effect. Simulations were conducted to assess the method's capability to separate APT from the fast exchange amine CEST effect. Animal experiments were performed to assess the relative contributions from the fast exchange amine and amide to CEST signals at 3.5 ppm. Three APT quantification methods, each with varying degrees of contamination from the fast exchange amine, were employed to process the animal data to assess the influence of the amine on the quantification of APT effect and the exchange parameters.
resultsThe relative size of the fast exchange amine CEST effect to APT effect gradually increases with increasing saturation power. At 9.4 T, it increases from approximately 20% to 40% of APT effect with a saturation power increase from 0.25 to 1 μT.
conclusionThe fast exchange amine CEST effect leads overestimation of APT effect, fitted amide concentration, and amide-water exchange rate, potentially contributing to the conflicting results reported in previous studies.
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