Evidence map›Paper›PMID 37317681›Full record

ArticleIJID regions2023

Primary series COVID-19 vaccine effectiveness among healthcare workers in Albania, February-December 2021.

Julia E Rubin-Smith, Madelyn Yiseth Rojas Castro, Iria Preza, Iris Hasibra, Jonilda Sulo, Albana Fico, Rovena Daja, Adela Vasili, Majlinda Kota, Alexis Schmid and 12 more

Abstract read
In one paragraph

Article in IJID regions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Julia E Rubin-SmithGlobal Health Program, Boston Children's Hospital, Boston, MA, USA.
Madelyn Yiseth Rojas CastroEpiconcept, Paris, France.
Iria PrezaInstitute of Public Health, Tirana, Albania.
Iris HasibraInstitute of Public Health, Tirana, Albania.
Jonilda SuloSoutheast European Centre for Surveillance and Control of Infectious Disease, Tirana, Albania.
Albana FicoInstitute of Public Health, Tirana, Albania.
Rovena DajaInstitute of Public Health, Tirana, Albania.
Adela VasiliInstitute of Public Health, Tirana, Albania.
Majlinda KotaInstitute of Public Health, Tirana, Albania.
Alexis SchmidGlobal Health Program, Boston Children's Hospital, Boston, MA, USA.
Shela SridharGlobal Health Program, Boston Children's Hospital, Boston, MA, USA.
Alina GuseinovaWorld Health Organization Regional Office for Europe, Copenhagen, Denmark.
Golubinka BoshevskaWorld Health Organization Regional Office for Europe, Copenhagen, Denmark.
Gazmend BejtjaWorld Health Organization Regional Office for Europe, Copenhagen, Denmark.
Barbara MühlemannInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Christian DrostenInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Pernille JorgensenWorld Health Organization Regional Office for Europe, Copenhagen, Denmark.
Richard PebodyWorld Health Organization Regional Office for Europe, Copenhagen, Denmark.
Esther KisslingEpiconcept, Paris, France.
Kathryn E LafondInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Mark A KatzWorld Health Organization Regional Office for Europe, Copenhagen, Denmark.
Silvia BinoInstitute of Public Health, Tirana, Albania.

Funding

NEVADA IMMUNIZATION INTEROPERABILITY CAPACITY BUILDING U38IP000873 · IP · HEALTH AND HUMAN SERVICES, NEVADA DEPARTMENT OF · PI MACKIE, CHRISTINE N · 2015 to 2015
$625k
NCIRD CDC HHS U38 IP000873World Health Organization 001
6 · The paper itself

Abstract

Background: Healthcare workers have experienced high rates of morbidity and mortality from coronavirus disease 2019 (COVID-19). Methods: A prospective cohort study was conducted in three Albanian hospitals between 19 February and 14 December 2021. All participants underwent polymerase chain reaction (PCR) and serological testing at enrolment, regular serology throughout, and PCR testing when symptomatic.Vaccine effectiveness (VE) against COVID-19 and against all severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections (symptomatic or asymptomatic) was estimated. VE was estimated using a Cox regression model, with vaccination status as a time-varying variable. Findings: In total, 1504 HCWs were enrolled in this study; 70% had evidence of prior SARS-CoV-2 infection. VE was 65.1% [95% confidence interval (CI) 37.7-80.5] against COVID-19, 58.2% (95% CI 15.7-79.3) among participants without prior SARS-CoV-2 infection, and 73.6% (95% CI 24.3-90.8) among participants with prior SARS-CoV-2 infection. For BNT162b2 alone, VE was 69.5% (95% CI 44.5-83.2). During the period when the Delta variant was predominant, VE was 67.1% (95% CI 38.3-82.5). VE against SARS-CoV-2 infection for the full study period was 36.9% (95% CI 15.8-52.7). Interpretation: This study found moderate primary series VE against COVID-19 among healthcare workers in Albania. These results support the continued promotion of COVID-19 vaccination in Albania, and highlight the benefits of vaccination in populations with high levels of prior infection.

Indexed as

AlbaniaCOVID-19 vaccineDelta variantHealthcare workersHybrid immunityVaccine effectiveness

Identifiers

PMID37317681
PMCPMC10106115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.