ReviewMicroorganisms2023
Development of the Neonatal Intestinal Barrier, Microbiome, and Susceptibility to NEC.
Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neonatal Fungemia by Non-Candida Rare Opportunistic Yeasts: A Systematic Review of Literature.International journal of molecular sciences · 2024Pooled it
- Early total enteral feeding versus conventional incremental feeding in preterm infants weighing 1000-1250 g: a single-center open-label randomized controlled trial.European journal of pediatrics · 2026Trial
- Reduced gut microbiota-derived indole-3-carboxaldehyde and 5-hydroxyindole-3-acetic acid are associated with intestinal barrier dysfunction and inflammation in diarrheic suckling lambs.Journal of animal science and biotechnology · 2026Article
- Protein-Based Probiotic Delivery Systems: Structural Basis, Functional Roles, and Food Applications.Comprehensive reviews in food science and food safety · 2026Review
- Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment.Journal of translational medicine · 2026Review
- The human breast milk microbiome: a landscape review of its composition, origins, and impact on infant health.Archives of microbiology · 2026Review
- Early-life gastrointestinal inflammation and the developing brain: Unravelling the pathways to long-term cognitive dysfunction.World journal of clinical pediatrics · 2026Review
- Immune-microbe interactions in pediatric ulcerative colitis: clinical features, pathogenesis, and novel targeted therapeutic strategies.Frontiers in immunology · 2026Review
- Breastmilk microbiota and its association with infant iron deficiency anaemia: A 16S rRNA metagenomic study in Peruvian mothers cohort.PloS one · 2026Article
- Ferroptosis in necrotizing enterocolitis: iron overload-driven intestinal injury and mechanistic insights.Frontiers in pediatrics · 2026Review
- Review: microbial metabolites - a key to address gut inflammation and barrier dysfunction in the premature infant.Gut microbes · 2025Review
- Intestinal metabolomics analysis reveals lysophosphatidylcholine is the key regulatory metabolite in mouse models of necrotizing enterocolitis.Scientific reports · 2025Article
- Dynamic Interactions between the Gut Microbiome, Health, and Metabolic Disorders in Preterm Infants.Journal of microbiology and biotechnology · 2025Review
- Ultrasound for the Early Detection and Diagnosis of Necrotizing Enterocolitis: A Scoping Review of Emerging Evidence.Diagnostics (Basel, Switzerland) · 2025Review
- A developmental role for toll like receptor 4 in the neonatal intestine.Pediatric research · 2025Article
- Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.Mucosal immunology · 2025Review
- Mutual Interactions Between Microbiota and the Human Immune System During the First 1000 Days of Life.Biology · 2025Review
- Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function.Scientific reports · 2025Article
- First-year dynamics of the anaerobic microbiome and archaeome in infants' oral and gastrointestinal systems.mSystems · 2025Article
- Mucus and mucin: changes in the mucus barrier in disease states.Tissue barriers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The function of the intestinal barrier is partially dependent on host maturity and the colonization patterns of the microbiome to which it is exposed. Premature birth and stressors of neonatal intensive care unit (NICU)-related support (e.g., antibiotics, steroids, etc.) can alter the host internal environment resulting in changes in the intestinal barrier. Pathogenic microbial proliferation and breach of the immature intestinal barrier are proposed to be crucial steps in the development of neonatal diseases such as necrotizing enterocolitis. This article will review the current literature on the intestinal barrier in the neonatal gut, the consequences of microbiome development for this defense system, and how prematurity can influence neonatal susceptibility to gastrointestinal infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.