Evidence map›Paper›PMID 37317053›Full record

ArticleCancer science2023

Splicing factor TRA2A contributes to esophageal cancer progression via a noncanonical role in lncRNA m

Mingrong Bei, Shijia Hao, Kai Lin, Qiuyang Chen, Yujie Cai, Xing Zhao, Leiming Jiang, Lirui Lin, Geng Dong, Jianzhen Xu

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Cross-talk of mFrontiers in immunology · 2025
    Article
  7. Review
  8. SR proteins in cancer: function, regulation, and small inhibitor.Cellular & molecular biology letters · 2024
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mingrong BeiSystems Biology Laboratory, Shantou University Medical College (SUMC), Shantou, China.
Shijia HaoSystems Biology Laboratory, Shantou University Medical College (SUMC), Shantou, China.
Kai LinDepartment of Biochemistry and Molecular Biology, Shantou University Medical College (SUMC), Shantou, China.
Qiuyang ChenSystems Biology Laboratory, Shantou University Medical College (SUMC), Shantou, China.
Yujie CaiGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Xing ZhaoSystems Biology Laboratory, Shantou University Medical College (SUMC), Shantou, China.
Leiming JiangSystems Biology Laboratory, Shantou University Medical College (SUMC), Shantou, China.
Lirui LinSystems Biology Laboratory, Shantou University Medical College (SUMC), Shantou, China.
Geng DongDepartment of Biochemistry and Molecular Biology, Shantou University Medical College (SUMC), Shantou, China.
Jianzhen XuSystems Biology Laboratory, Shantou University Medical College (SUMC), Shantou, China.ORCID https://orcid.org/0000-0002-0697-9075
Shantou University · CNGuangdong Medical College · CNUniversity Medical Center Groningen · NL

Funding

Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology
6 · The paper itself

Abstract

Transformer 2 alpha homolog (TRA2A), a member of the serine/arginine-rich splicing factor family, has been shown to control mRNA splicing in development and cancers. However, it remains unclear whether TRA2A is involved in lncRNA regulation. In the present study, we found that TRA2A was upregulated and correlated with poor prognosis in esophageal cancer. Downregulation of TRA2A suppressed the tumor growth in xenograft nude mice. Epitranscriptomic microarray showed that depletion of TRA2A affected global lncRNA methylation similarly to the key m

Indexed as

Esophageal NeoplasmsRNA, Long NoncodingAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMethylationMethyltransferasesMiceMice, NudeNebivololRNA Splicing FactorsMethyltransferasesMETTL3 protein, humanNebivololRNA, Long NoncodingRNA Splicing Factorsesophageal cancerLncRNA methylationMALAT1splicing factorTRA2A

Identifiers

PMID37317053
PMCPMC10394134
OpenAlexW4380681155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.