Evidence map›Paper›PMID 37317027›Full record

ArticleGut microbes2023

Faecal Microbiota transplantation affects liver DNA methylation in Non-alcoholic fatty liver disease: a multi-omics approach.

Daniela Stols-Gonçalves, Anne Linde Mak, Mette S Madsen, Eduard W J van der Vossen, Eveline Bruinstroop, Peter Henneman, Femke Mol, Torsten P M Scheithauer, Loek Smits, Julia Witjes and 5 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 59 citations in OpenAlex.

  1. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. The gut-joint axis in osteoarthritis.Nature reviews. Rheumatology · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Gut Microbiota-Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Daniela Stols-GonçalvesDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Anne Linde MakDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Mette S MadsenGubra, Hørsholm, Denmark.
Eduard W J van der VossenDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Eveline BruinstroopAmsterdam Gastroenterology Endocrinology Metabolism (AGEM) Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Peter HennemanAmsterdam Gastroenterology Endocrinology Metabolism (AGEM) Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Femke MolDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Torsten P M ScheithauerDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Loek SmitsDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Julia WitjesDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Abraham Stijn MeijnikmanDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Joanne VerheijAmsterdam Gastroenterology Endocrinology Metabolism (AGEM) Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Max NieuwdorpDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Adriaan G HolleboomDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
Evgeni LevinDepartment of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
University of Amsterdam · NLAmsterdam University Medical Centers · NLGubra (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with nonalcoholic fatty liver disease (NAFLD) have an altered gut microbiota composition. Moreover, hepatic DNA methylation may be altered in the state of NAFLD. Using a fecal microbiota transplantation (FMT) intervention, we aimed to investigate whether a change in gut microbiota composition relates to altered liver DNA methylation in NAFLD. Moreover, we assessed whether plasma metabolite profiles altered by FMT relate to changes in liver DNA methylation. Twenty-one individuals with NAFLD underwent three 8-weekly vegan allogenic donor (

Indexed as

Gastrointestinal MicrobiomeNon-alcoholic Fatty Liver DiseaseCholineDNA MethylationFecal Microbiota TransplantationHumansMultiomicsCholineDNA methylationfaecal microbiota transplantation (FMT)multi-omics analysisnon-alcoholic fatty liver disease (NAFLD)

Identifiers

PMID37317027
PMCPMC10269428
OpenAlexW4380681050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.