Evidence map›Paper›PMID 37317012›Full record

ArticleGut microbes

Systemic exposure to bacterial amyloid curli alters the gut mucosal immune response and the microbiome, exacerbating

Shingo Bessho, Kaitlyn C M Grando, Kathrine Kyrylchuk, Amanda Miller, Andres J Klein-Szanto, Wenhan Zhu, Stefania Gallucci, Vincent Tam, Çagla Tükel

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Amyloid, Crohn's disease, and Alzheimer's disease - are they linked?Frontiers in cellular and infection microbiology · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shingo BesshoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Kaitlyn C M GrandoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Kathrine KyrylchukCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Amanda MillerCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Andres J Klein-SzantoHistopathology Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Wenhan ZhuDepartment of Pathology Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Stefania GallucciDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Vincent TamCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Çagla TükelCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Temple University · USFox Chase Cancer Center · USUniversity of Massachusetts Chan Medical School · USVanderbilt University Medical Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
The role of bacterial amyloid curli in Alzheimer's DiseaseR01AI153325 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2024
$2.4M
Commensal resilience mechanisms in the inflamed intestineR35GM147470 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2022 to 2026
$2.2M
The Role of Eicosanoid-PPAR axis in Exacerbating Post-Influenza Staphylococcus aureus Super-infectionR01AI168550 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI Vincent Tam · 2022 to 2026
$2.0M
Commensal bacteria resilience mechanisms in the inflamed intestineR01DK134692 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2023 to 2026
$1.4M
Immune recognition mechanisms of bacterial biofilms in the gutR21AI151893 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2021
$436k
Pathogenicity of amyloid containing biofilmsR21AI148770 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2021
$436k
NCI NIH HHS P30 CA006927NIAID NIH HHS R01 AI153325NIAID NIH HHS R01 AI168550NIAID NIH HHS R21 AI148770NIAID NIH HHS R21 AI151893NIDDK NIH HHS R01 DK134692NIGMS NIH HHS R35 GM147470
6 · The paper itself

Abstract

The

Indexed as

ArthritisGastrointestinal MicrobiomeMicrobiotaSalmonella InfectionsAmyloidogenic ProteinsAnimalsBacteroidetesHumansImmunity, MucosalInflammationMiceMice, Inbred C57BLAmyloidogenic Proteinsamyloidautoimmunitybiofilmcurlimicrobiomereactive arthritisSalmonella

Identifiers

PMID37317012
PMCPMC10269392
OpenAlexW4380730200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.