Evidence map›Paper›PMID 37316944›Full record

ArticleBiomedical engineering online2023

Investigation of total skin helical tomotherapy using a 3D-printed total skin bolus.

Haiyang Wang, Yifei Pi, Chunbo Liu, Xin Wang, Yuexin Guo, Lei Lu, Xi Pei, Xie George Xu

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical engineering online, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Application of 3D printing for personalized boluses in radiotherapy: a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Haiyang Wang *Institute of Nuclear Medical Physics, University of Science and Technology of China, Hefei, China.
Yifei Pi *Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chunbo LiuDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xin WangDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuexin GuoDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lei LuCollege of Information Science and Engineering, Henan University of Technology, Zhengzhou, China.
Xi PeiInstitute of Nuclear Medical Physics, University of Science and Technology of China, Hefei, China.
Xie George XuInstitute of Nuclear Medical Physics, University of Science and Technology of China, Hefei, China. xgxu@ustc.edu.cn.
First Affiliated Hospital of Zhengzhou University · CNUniversity of Science and Technology of China · CNHenan University of Technology · CN

Funding

China International Medical Foundation Tumor Precision Radiotherapy Spark Program Clinical Research Fund HDRS2020010110Henan Province Medical Science and Technology Research Program Provincial and Ministry Co-constructed Youth Project SBGJ202103073Joint Construction Project of Henan Province Medical Science and Technology Research Program LHGJ20190161Key Scientific Research Projects of Henan Provincial Colleges and Universities 23B320004Natural Science Foundation of Anhui Province 1908085MA27
6 · The paper itself

Abstract

objectiveTo investigate the effectiveness of using a 3D-printed total skin bolus in total skin helical tomotherapy for the treatment of mycosis fungoides. MATERIALS AND

methodsA 65-year-old female patient with a 3-year history of mycosis fungoides underwent treatment using an in-house desktop fused deposition modelling printer to create a total skin bolus made of a 5-mm-thick flexible material, which increased the skin dose through dose building. The patient's scan was segmented into upper and lower sections, with the division line placed 10 cm above the patella. The prescription was to deliver 24 Gy over 24 fractions, given 5 times per week. The plan parameters consisted of a field width of 5 cm, pitch of 0.287 and modulation factor of 3. The complete block was placed 4 cm away from the planned target region to reduce the area of the internal organs at risk, especially the bone marrow. Dose delivery accuracy was verified using point dose verification with a "Cheese" phantom (Gammex RMI, Middleton, WI), 3D plane dose verification with ArcCHECK (Model 1220, Sun Nuclear, Melbourne, FL), and multipoint film dose verification. Megavoltage computed tomography guidance was also utilized to ensure the accuracy of the setup and treatment.

resultsA 5-mm-thick 3D-printed suit was used as a bolus to achieve a target volume coverage of 95% of the prescribed dose. The conformity index and homogeneity index of the lower segment were slightly better than those of the upper segment. As the distance from the skin increased, the dose to the bone marrow gradually decreased, and the dose to other organs at risk remained within clinical requirements. The point dose verification deviation was less than 1%, the 3D plane dose verification was greater than 90%, and the multipoint film dose verification was less than 3%, all of which confirmed the accuracy of the delivered dose. The total treatment time was approximately 1.5 h, which included 0.5 h of wearing the 3D-printed suit and 1 h with the beam on. Patients only experienced mild fatigue, nausea or vomiting, low-grade fever, and grade III bone marrow suppression.

conclusionThe use of a 3D-printed suit for total skin helical tomotherapy can result in a uniform dose distribution, short treatment time, simple implementation process, good clinical outcomes, and low toxicity. This study presents an alternative treatment approach that can potentially yield improved clinical outcomes for mycosis fungoides.

Indexed as

Mycosis FungoidesRadiotherapy, Intensity-ModulatedSkin NeoplasmsAgedFemaleHumansPrinting, Three-DimensionalSkin3D printingMycosis fungoidesTotal skin bolusTotal skin helical tomotherapy

Identifiers

PMID37316944
PMCPMC10268392
OpenAlexW4380608055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.